Literature DB >> 9246044

Granulomatous hepatitis in a patient with chronic hepatitis C treated with interferon-alpha.

M P Veerabagu1, S D Finkelstein, M Rabinovitz.   

Abstract

Common adverse effects of IFN-alpha include flulike symptoms, headache, irritability, and bone marrow suppression. Hepatic side effects are unusual except in patients with pretreatment autoimmune hepatitis. Granuloma formation in the liver as a result of IFN-alpha therapy has never been reported. We described a 48-year-old female with chronic hepatitis C infection who developed granulomatous hepatitis following treatment with IFN-alpha. The granulomatous inflammation resolved after discontinuation of IFN-alpha treatment. Possible mechanisms for this unusual occurrence are discussed.

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Year:  1997        PMID： 9246044     DOI： 10.1023/a:1018806508474

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  14 in total

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Journal:  Hepatology       Date:  1992-04       Impact factor: 17.425

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Journal:  Hepatology       Date:  1992-04       Impact factor: 17.425

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Journal:  Lab Invest       Date:  1981-01       Impact factor: 5.662

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Authors:  G L Davis; L A Balart; E R Schiff; K Lindsay; H C Bodenheimer; R P Perrillo; W Carey; I M Jacobson; J Payne; J L Dienstag
Journal:  N Engl J Med       Date:  1989-11-30       Impact factor: 91.245

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Journal:  Mayo Clin Proc       Date:  1991-09       Impact factor: 7.616

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Journal:  Cancer       Date:  1987-03-01       Impact factor: 6.860

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Journal:  Science       Date:  1989-04-21       Impact factor: 47.728

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Authors:  A McInnes; D M Rennick
Journal:  J Exp Med       Date:  1988-02-01       Impact factor: 14.307
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  3 in total

1.  Sarcoidosis-associated hepatitis C virus infection.

Authors:  F Bonnet; P Morlat; J Dubuc; S De Witte; M Bonarek; N Bernard; D Lacoste; J Beylot
Journal:  Dig Dis Sci       Date:  2002-04       Impact factor: 3.199

2.  Prevalence of hepatic granulomas in chronic hepatitis B.

Authors:  Veysel Tahan; Resat Ozaras; Nadir Lacevic; Ercan Ozden; Mucahit Yemisen; Osman Ozdogan; Ali Mert; Fehmi Tabak; Erol Avsar; Cigdem Ataizi Celikel; Gulsen Ozbay; Cem Kalayci; Hakan Senturk; Nurdan Tozun
Journal:  Dig Dis Sci       Date:  2004-10       Impact factor: 3.199

3.  Hepatic granulomas: a 10 year single centre experience.

Authors:  D R Gaya; D Thorburn; K A Oien; A J Morris; A J Stanley
Journal:  J Clin Pathol       Date:  2003-11       Impact factor: 3.411
  3 in total

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