Literature DB >> 9245712

Isolation of 1-methyl-1,2,3,4-tetrahydroisoquinoline-synthesizing enzyme from rat brain: a possible Parkinson's disease-preventing enzyme.

T Yamakawa1, S Ohta.   

Abstract

An endogenous parkinsonism-preventing substance, 1-methyl-1,2,3,4-tetrahydroisoquinoline, is enzymatically formed from 2-phenethylamine and pyruvate in rat brain. The enzyme involved was localized in the mitochondrial-synaptosomal fraction of rat brain, solubilized by treatment with sodium deoxycholate. In order to purify the enzyme, gel filtration was carried out. This enzyme may be important in the pathogenesis of Parkinson's disease.

Entities:  

Mesh：

Substances：

Year:  1997        PMID： 9245712     DOI： 10.1006/bbrc.1997.6946

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

Review 1.  Not Just from Ethanol. Tetrahydroisoquinolinic (TIQ) Derivatives: from Neurotoxicity to Neuroprotection.

Authors:  Alessandra T Peana; Valentina Bassareo; Elio Acquas
Journal:  Neurotox Res       Date:  2019-05-02       Impact factor: 3.911

2.  1-Methyl-1,2,3,4-tetrahydroisoquinoline antagonizes a rise in brain dopamine metabolism, glutamate release in frontal cortex and locomotor hyperactivity produced by MK-801 but not the disruptions of prepulse inhibition, and impairment of working memory in rat.

Authors:  Małgorzata Pietraszek; Jerzy Michaluk; Irena Romańska; Agnieszka Wasik; Krystyna Gołembiowska; Lucyna Antkiewicz-Michaluk
Journal:  Neurotox Res       Date:  2009-08-01       Impact factor: 3.911

3.  Effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline on the protective action of various antiepileptic drugs in the maximal electroshock-induced seizure model: a type II isobolographic analysis.

Authors:  Marta Andres-Mach; Anna Zadrożniak; Agnieszka Haratym-Maj; Magdalena Florek-Luszczki; Grzegorz Raszewski; Lucyna Antkiewicz-Michaluk; Jarogniew J Luszczki
Journal:  J Neural Transm (Vienna)       Date:  2013-06-07       Impact factor: 3.575

4.  Neuroprotective Effect of the Endogenous Amine 1MeTIQ in an Animal Model of Parkinson's Disease.

Authors:  Agnieszka Wąsik; Irena Romańska; Jerzy Michaluk; Agnieszka Zelek-Molik; Irena Nalepa; Lucyna Antkiewicz-Michaluk
Journal:  Neurotox Res       Date:  2015-08-25       Impact factor: 3.911

5.  Antidepressant-Like Effect of the Endogenous Neuroprotective Amine, 1MeTIQ in Clonidine-Induced Depression: Behavioral and Neurochemical Studies in Rats.

Authors:  Lucyna Antkiewicz-Michaluk; Irena Romańska; Agnieszka Wąsik; Jerzy Michaluk
Journal:  Neurotox Res       Date:  2017-04-03       Impact factor: 3.911

6.  The Protective Effect of Repeated 1MeTIQ Administration on the Lactacystin-Induced Impairment of Dopamine Release and Decline in TH Level in the Rat Brain.

Authors:  Agnieszka Wąsik; Irena Romańska; Agnieszka Zelek-Molik; Irena Nalepa; Lucyna Antkiewicz-Michaluk
Journal:  Neurotox Res       Date:  2018-08-20       Impact factor: 3.911

Review 7.  Neurotoxicity and Underlying Mechanisms of Endogenous Neurotoxins.

Authors:  Yanlu Cao; Bo Li; Nafissa Ismail; Kevin Smith; Tianmei Li; Rongji Dai; Yulin Deng
Journal:  Int J Mol Sci       Date:  2021-11-26       Impact factor: 5.923

Review 8.  1-Methyl-1,2,3,4-tetrahydroisoquinoline, an endogenous amine with unexpected mechanism of action: new vistas of therapeutic application.

Authors:  Lucyna Antkiewicz-Michaluk; Agnieszka Wąsik; Jerzy Michaluk
Journal:  Neurotox Res       Date:  2013-05-30       Impact factor: 3.911

9.  Comparison of the Effects of Acute and Chronic Administration of Tetrahydroisoquinoline Amines on the In Vivo Dopamine Release: A Microdialysis Study in the Rat Striatum.

Authors:  Agnieszka Wąsik; Irena Romańska; Lucyna Antkiewicz-Michaluk
Journal:  Neurotox Res       Date:  2016-08-27       Impact factor: 3.911
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.