| Literature DB >> 9243618 |
K W Johnson1, J M Schaus, M M Durkin, J E Audia, S W Kaldor, M E Flaugh, N Adham, J M Zgombick, M L Cohen, T A Branchek, L A Phebus.
Abstract
The serotonin (5-HT) receptor subtype mediating inhibition of neurogenic dural inflammation in guinea pigs was investigated using a series of serotonin agonists with differing affinities for the 5-HT1B, 5-HT1D and 5-HT1F receptors. When agonist potencies for inhibiting neurogenic inflammation were compared with affinities for these receptor subtypes, a significant positive correlation was seen only with the 5-HT1F receptor. The potency of agonists in inhibiting adenylate cyclase in cells transfected with human 5-HT1F receptor was also highly correlated with their potency in the animal model of migraine. In situ hybridization demonstrated 5-HT1F receptor mRNA in guinea pig trigeminal ganglion neurons. These data suggest that the 5-HT1F receptor is a rational target for migraine therapeutics.Entities:
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Year: 1997 PMID： 9243618 DOI： 10.1097/00001756-199707070-00029
Source DB: PubMed Journal: Neuroreport ISSN： 0959-4965 Impact factor: 1.837