Literature DB >> 9242930

Complement activation and thromboxane secretion by liposome-encapsulated hemoglobin in rats in vivo: inhibition by soluble complement receptor type 1.

J Szebeni1, H Spielberg, R O Cliff, N M Wassef, A S Rudolph, C R Alving.   

Abstract

Intravenous administration of liposome-encapsulated hemoglobin (LEH) in rats led to an early (within 15 min) decline of hemolytic complement (C) activity in the plasma along with a significant, parallel rise in thromboxane B2 (TXB2) levels. The TXB2 response was inhibited by co-administration of soluble C receptor type 1 (sCR1) with LEH, as well as by C depletion with cobra venom factor. These observations provide evidence for a causal relationship between LEH-induced C activation and TXB2 release, and suggest that sCR1 could be useful in attenuating the acute respiratory, hematological and hemodynamic side effects of LEH described earlier in the rat.

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Year:  1997        PMID： 9242930     DOI： 10.3109/10731199709118925

Source DB:  PubMed          Journal:  Artif Cells Blood Substit Immobil Biotechnol        ISSN： 1073-1199


  5 in total

1.  Post-modification of preformed liposomes with novel non-phospholipid poly(ethylene glycol)-conjugated hexadecylcarbamoylmethyl hexadecanoic acid for enhanced circulation persistence in vivo.

Authors:  Okhil K Nag; Vivek R Yadav; Andria Hedrick; Vibhudutta Awasthi
Journal:  Int J Pharm       Date:  2013-02-16       Impact factor: 5.875

2.  Biological evaluation of liposome-encapsulated hemoglobin surface-modified with a novel PEGylated nonphospholipid amphiphile.

Authors:  Vivek R Yadav; Okhil Nag; Vibhudutta Awasthi
Journal:  Artif Organs       Date:  2014-04-22       Impact factor: 3.094

Review 3.  Human Clinical Relevance of the Porcine Model of Pseudoallergic Infusion Reactions.

Authors:  János Szebeni; Raj Bawa
Journal:  Biomedicines       Date:  2020-04-08

4.  Complement Activation-Related Pathophysiological Changes in Anesthetized Rats: Activator-Dependent Variations of Symptoms and Mediators of Pseudoallergy.

Authors:  László Dézsi; Tamás Mészáros; Erik Őrfi; Tamás G Fülöp; Mark Hennies; László Rosivall; Péter Hamar; János Szebeni; Gábor Szénási
Journal:  Molecules       Date:  2019-09-09       Impact factor: 4.411

5.  PEGylated Liposomal Methyl Prednisolone Succinate does not Induce Infusion Reactions in Patients: A Correlation Between in Vitro Immunological and in Vivo Clinical Studies.

Authors:  Yaelle Bavli; Bing-Mae Chen; Steve R Roffler; Marina A Dobrovolskaia; Eldad Elnekave; Shifra Ash; Yechezkel Barenholz; Keren Turjeman
Journal:  Molecules       Date:  2020-01-28       Impact factor: 4.411
  5 in total

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