Literature DB >> 924274

Strain improvement in Streptomyces galilaeus, a producer of anthracycline antibiotics galirubins.

E Královocová, M Blumauerová, Z Vanĕk.   

Abstract

The production of epsilon-pyrromycinone glycosides in Streptomyces galilaeus increased 12-fold, with respect to the wild strain, as a result of a sequential procedure including both natural selection and treatment with mutagens (nitrous acid, UV light and gamma-irradiation). Nitrous acid exhibited the highest mutagenic effect, both in increasing the productivity and in inducing blocked mutants. A mutant strain blocked in the biosynthesis of glycosides and accumulating free epsilon-pyrromycinone as the principal metabolite was obtained.

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Year:  1977        PMID： 924274     DOI： 10.1007/bf02877666

Source DB:  PubMed          Journal:  Folia Microbiol (Praha)        ISSN： 0015-5632            Impact factor:   2.099


  16 in total

1.  Production of carminomycin by auxotrophic mutants of Actinomadura carminata.

Authors:  O A Lapchinskaya; T A Saburova; V I Ponomarenko
Journal:  Z Allg Mikrobiol       Date:  1975

2.  Genetics of organisms producing tetracyclines.

Authors:  S I ALIKHANIAN; S Z MINDLIN; S U GOLDAT; A V VLADIMIZOV
Journal:  Ann N Y Acad Sci       Date:  1959-09-30       Impact factor: 5.691

3.  Induced mutation and strain selection in some industrially important microorganisms.

Authors:  E L DULANEY
Journal:  Ann N Y Acad Sci       Date:  1954-10-29       Impact factor: 5.691

4.  [Spontaneous and induced variability in Actinomyces rubiginosohelvolus, a new producer of the antibiotic rubomycin].

Authors:  O A Lapchinskaia; T P Saburova; O P Siniagina; N V Konstantinova; V A Filicheva
Journal:  Antibiotiki       Date:  1975

5.  The effect of 5,5-diethylbarbituric acid on the biosynthesis of anthracyclines in Streptomyces galilaeus.

Authors:  E Královcová; M Blumauerová; Z Vanĕk
Journal:  Folia Microbiol (Praha)       Date:  1977       Impact factor: 2.099

Review 6.  How do antibiotic-producing microorganisms avoid suicide?

Authors:  A L Demain
Journal:  Ann N Y Acad Sci       Date:  1974-05-10       Impact factor: 5.691

7.  The study of variability and strain selection in Streptomyces atroolivaceus. I. UV light and nitrous acid as effective agents in the improvement of mithramycin production.

Authors:  M Blumauerová; A S Callieri; K Stajner; Z Vanĕk
Journal:  Folia Microbiol (Praha)       Date:  1974       Impact factor: 2.099

8.  [On the identification of a series of anthracycline pigments from Streptomyces galilaeus Stamm JA 3043 (galirubine and galirubinone)].

Authors:  K Eckardt
Journal:  Chem Ber       Date:  1967

9.  [Production of glycosides of epsilon pyrromycinons (galirubine) during the cultivation of Streptomyces galilaeus].

Authors:  E Královcová; J Tax; M Blumauerová; Z Vanĕk
Journal:  Z Allg Mikrobiol       Date:  1977

10.  Use of mutagens in the improvement of production strains of microorganisms.

Authors:  R W Thoma
Journal:  Folia Microbiol (Praha)       Date:  1971       Impact factor: 2.099
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  8 in total

1.  Growth and production of anthracyclines in wild-type and mutant strains of Streptomyces galilaeus.

Authors:  E Královcová; Z Vanĕk
Journal:  Folia Microbiol (Praha)       Date:  1979       Impact factor: 2.099

2.  Intra- and interspecific cosynthetic activity of mutants of Streptomyces coeruleorubidus and Streptomyces galilaeus impaired in the biosynthesis of anthracyclines.

Authors:  M Blumauerová; E Královocová; Z Hostálek; Z Vanĕk
Journal:  Folia Microbiol (Praha)       Date:  1979       Impact factor: 2.099

3.  Biotransformations of anthracyclinones in Streptomyces coeruleorubidus and Streptomyces galilaeus.

Authors:  M Blumauerová; E Královcová; J Matĕjů; J Jizba; Z Vanĕk
Journal:  Folia Microbiol (Praha)       Date:  1979       Impact factor: 2.099

4.  Spontaneous and induced variability in Streptomyces nogalater producing nogalamycin.

Authors:  K Klánová; M Blumauerová; Z Vanĕk
Journal:  Folia Microbiol (Praha)       Date:  1977       Impact factor: 2.099

5.  Effect of aeration efficiency and carbon source on the production of anthracyclines in Streptomyces galilaeus.

Authors:  E Královcová; Z Vanĕk
Journal:  Folia Microbiol (Praha)       Date:  1979       Impact factor: 2.099

6.  Mutants of Streptomyces coeruleorubidus impaired in the biosynthesis of daunomycinone glycosides and related metabolites.

Authors:  M Blumauerová; K Stajner; V Pokorný; Z Hostálek; Z Vanĕk
Journal:  Folia Microbiol (Praha)       Date:  1978       Impact factor: 2.099

7.  Improved yields of daunomycinone glycosides in developmental mutants of Streptomyces coeruleorubidus.

Authors:  M Blumauerová; V Pokorný; J Stastná; Z Hostálek; Z Vanĕk
Journal:  Folia Microbiol (Praha)       Date:  1978       Impact factor: 2.099

8.  Evaluation of the anticarcinogenic potential of the endophyte, Streptomyces sp. LRE541 isolated from Lilium davidii var. unicolor (Hoog) Cotton.

Authors:  Aiai Ma; Kan Jiang; Bin Chen; Shasha Chen; Xinge Qi; Huining Lu; Junlin Liu; Xuan Zhou; Tan Gao; Jinhui Li; Changming Zhao
Journal:  Microb Cell Fact       Date:  2021-12-04       Impact factor: 5.328
  8 in total

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