OBJECTIVE: To compare the efficacy of nifedipine with ritodrine in the management of preterm labor. METHODS:One hundred eighty-five singleton pregnancies with preterm labor were assigned randomly to either ritodrine intravenously (n = 90) or nifedipine orally (n = 95). The principal outcome assessed was delay of delivery. RESULTS:Ritodrine was discontinued in 12 patients because of severe maternal side effects, and their results were excluded from further analysis. More women in the ritodrine group delivered within 24 hours (22 versus 11, P = .006), within 48 hours (29 versus 21, P = .03), within 1 week (45 versus 36, P = .009), and within 2 weeks (52 versus 43, P = .005) compared with those receiving nifedipine. There were significantly fewer maternal side effects in the nifedipine group. Apgar scores and umbilical artery and vein pHs were similar in both groups. The number of admissions to the neonatal intensive care unit (NICU) in the nifedipine group was significantly lower than in the ritodrine group (68.4 versus 82.1%, P = .04). CONCLUSION:Nifedipine in comparison with ritodrine in the management of preterm labor is significantly associated with a longer postponement of deliver, fewer maternal side effects, and fewer admissions to the NICU.
RCT Entities:
OBJECTIVE: To compare the efficacy of nifedipine with ritodrine in the management of preterm labor. METHODS: One hundred eighty-five singleton pregnancies with preterm labor were assigned randomly to either ritodrine intravenously (n = 90) or nifedipine orally (n = 95). The principal outcome assessed was delay of delivery. RESULTS:Ritodrine was discontinued in 12 patients because of severe maternal side effects, and their results were excluded from further analysis. More women in the ritodrine group delivered within 24 hours (22 versus 11, P = .006), within 48 hours (29 versus 21, P = .03), within 1 week (45 versus 36, P = .009), and within 2 weeks (52 versus 43, P = .005) compared with those receiving nifedipine. There were significantly fewer maternal side effects in the nifedipine group. Apgar scores and umbilical artery and vein pHs were similar in both groups. The number of admissions to the neonatal intensive care unit (NICU) in the nifedipine group was significantly lower than in the ritodrine group (68.4 versus 82.1%, P = .04). CONCLUSION:Nifedipine in comparison with ritodrine in the management of preterm labor is significantly associated with a longer postponement of deliver, fewer maternal side effects, and fewer admissions to the NICU.
Authors: Isabelle Fabry; Peter De Paepe; Jan Kips; Sebastian Vermeersch; Luc Van Bortel Journal: Eur J Clin Pharmacol Date: 2010-11-16 Impact factor: 2.953
Authors: Roel de Heus; Ben Willem Mol; Jan-Jaap H M Erwich; Herman P van Geijn; Wilfried J Gyselaers; Myriam Hanssens; Linda Härmark; Caroline D van Holsbeke; Johannes J Duvekot; Fred F A M Schobben; Hans Wolf; Gerard H A Visser Journal: BMJ Date: 2009-03-05
Authors: Carolien Roos; Liesbeth Hcj Scheepers; Kitty Wm Bloemenkamp; Annemiek Bolte; Jerome Cornette; Jan B Derks; Hans Jj Duvekot; Jim van Eyck; Joke H Kok; Anneke Kwee; Ashley Merién; Brent C Opmeer; Mariëlle G van Pampus; Dimitri Nm Papatsonis; Martina M Porath; Joris Am van der Post; Sicco A Scherjon; Krystyne Sollie; Marc Ea Spaanderman; Sylvia Mc Vijgen; Christine Willekes; Ben Willem J Mol; Fred K Lotgering Journal: BMC Pregnancy Childbirth Date: 2009-09-09 Impact factor: 3.007