BACKGROUND: Nearly 7 per cent of patients who undergo resection for colorectal cancer develop metachronous cancers several years later. A molecular marker that could identify patients susceptible to metachronous cancers would be of clinical importance. METHODS: Twenty-four colorectal cancers from 15 individuals with metachronous colorectal cancer were investigated for microsatellite instability at five loci by single stranded conformational polymorphism analysis. A control group of 14 colorectal cancers from individuals who had only developed one sporadic colorectal cancer each was analysed similarly. RESULTS: Microsatellite instability was demonstrated in 17 of 24 cancers from individuals with metachronous cancer compared with one of 14 cancers from individuals with a single colorectal cancer. CONCLUSION: These results suggest that testing for microsatellite instability may be useful in recognizing patients at high risk of developing metachronous colorectal cancers.
BACKGROUND: Nearly 7 per cent of patients who undergo resection for colorectal cancer develop metachronous cancers several years later. A molecular marker that could identify patients susceptible to metachronous cancers would be of clinical importance. METHODS: Twenty-four colorectal cancers from 15 individuals with metachronous colorectal cancer were investigated for microsatellite instability at five loci by single stranded conformational polymorphism analysis. A control group of 14 colorectal cancers from individuals who had only developed one sporadic colorectal cancer each was analysed similarly. RESULTS: Microsatellite instability was demonstrated in 17 of 24 cancers from individuals with metachronous cancer compared with one of 14 cancers from individuals with a single colorectal cancer. CONCLUSION: These results suggest that testing for microsatellite instability may be useful in recognizing patients at high risk of developing metachronous colorectal cancers.
Authors: K Yamashita; Y Arimura; S Kurokawa; F Itoh; T Endo; K Hirata; A Imamura; M Kondo; T Sato; K Imai Journal: Gut Date: 2000-06 Impact factor: 23.059
Authors: L Cawkwell; S Gray; H Murgatroyd; F Sutherland; L Haine; M Longfellow; S O'Loughlin; D Cross; O Kronborg; C Fenger; N Mapstone; M Dixon; P Quirke Journal: Gut Date: 1999-09 Impact factor: 23.059
Authors: Fernando S Velayos; Suk-Hwan Lee; Hongming Qiu; Sharon Dykes; Raymond Yiu; Jonathan P Terdiman; Julio Garcia-Aguilar Journal: J Gastrointest Surg Date: 2005-03 Impact factor: 3.452
Authors: Shin Hyuk Kim; Byung Kyu Ahn; Young Su Nam; Joo Youn Pyo; Young Ha Oh; Kang Hong Lee Journal: J Gastric Cancer Date: 2010-12-31 Impact factor: 3.720