Literature DB >> 9238638

Liquid-phase combinatorial synthesis: in search of small-molecule enzyme mimics.

A M Vandersteen1, H Han, K D Janda.   

Abstract

The applications, advantages and recent advances in liquid-phase combinatorial chemistry using poly-(ethyleneglycol) as a soluble polymer support are reviewed. Our recent efforts towards the synthesis of peptide-based catalysts on polyethyleneglycol are reported. The screening of libraries of peptides for catalysis is discussed.

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Year:  1996        PMID： 9238638     DOI： 10.1007/bf01718705

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  25 in total

Review 1.  How do serine proteases really work?

Authors:  A Warshel; G Naray-Szabo; F Sussman; J K Hwang
Journal:  Biochemistry       Date:  1989-05-02       Impact factor: 3.162

2.  Liquid-phase combinatorial synthesis.

Authors:  H Han; M M Wolfe; S Brenner; K D Janda
Journal:  Proc Natl Acad Sci U S A       Date:  1995-07-03       Impact factor: 11.205

Review 3.  Functionalized poly(ethylene glycol) for preparation of biologically relevant conjugates.

Authors:  S Zalipsky
Journal:  Bioconjug Chem       Date:  1995 Mar-Apr       Impact factor: 4.774

Review 4.  Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids.

Authors:  G B Fields; R L Noble
Journal:  Int J Pept Protein Res       Date:  1990-03

5.  Synthesis and catalytic properties of the pentapeptide, Thr-Ala-Cys-His-Asp.

Authors:  I Photaki; V Bardakos; A W Lake; G Lowe
Journal:  J Chem Soc Perkin 1       Date:  1968

6.  Preparation of some new biphenylisopropyloxycarbonyl amino acids and their application to the solid phase synthesis of a tryptophan-containing heptapeptide of bovine parathyroid hormone.

Authors:  S S Wang; R B Merrifield
Journal:  Int J Protein Res       Date:  1969

Review 7.  Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries.

Authors:  M A Gallop; R W Barrett; W J Dower; S P Fodor; E M Gordon
Journal:  J Med Chem       Date:  1994-04-29       Impact factor: 7.446

8.  Synthetic peptide models of enzyme active sites. 3. Stereoselective esterase models.

Authors:  J C Sheehan; G B Bennett; J A Schneider
Journal:  J Am Chem Soc       Date:  1966-07-20       Impact factor: 15.419

9.  Pegylated peptides. II. Solid-phase synthesis of amino-, carboxy- and side-chain pegylated peptides.

Authors:  Y A Lu; A M Felix
Journal:  Int J Pept Protein Res       Date:  1994-02

10.  Antibody catalysis of a disfavored chemical transformation.

Authors:  K D Janda; C G Shevlin; R A Lerner
Journal:  Science       Date:  1993-01-22       Impact factor: 47.728
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  1 in total

Review 1.  Composing life.

Authors:  D Segré; D Lancet
Journal:  EMBO Rep       Date:  2000-09       Impact factor: 8.807
  1 in total

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