Literature DB >> 9238632

Libraries from libraries: generation and comparison of screening profiles.

R A Houghten1, S E Blondelle, C T Dooley, B Dörner, J Eichler, J M Ostresh.   

Abstract

A positional scanning tetrapeptide library was chemically modified through alkylation and/or reduction of the amide bonds, thus generating three new combinatorial libraries with physico-chemical properties very different from the parent peptide library ('libraries from libraries'). Specific results were obtained with each of these libraries upon screening in kappa-opioid receptor binding and microdilution antimicrobial assays, illustrating the potential of the 'libraries from libraries' concept for the efficient generation of a variety of chemically diverse combinatorial libraries.

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Year:  1996        PMID： 9238632     DOI： 10.1007/bf01718699

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  9 in total

1.  Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries.

Authors:  C Pinilla; J R Appel; P Blanc; R A Houghten
Journal:  Biotechniques       Date:  1992-12       Impact factor: 1.993

2.  Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery.

Authors:  R A Houghten; C Pinilla; S E Blondelle; J R Appel; C T Dooley; J H Cuervo
Journal:  Nature       Date:  1991-11-07       Impact factor: 49.962

3.  General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

Authors:  R A Houghten
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

4.  The synthesis of peptidomimetic combinatorial libraries through successive amide alkylations.

Authors:  B Dörner; G M Husar; J M Ostresh; R A Houghten
Journal:  Bioorg Med Chem       Date:  1996-05       Impact factor: 3.641

Review 5.  Peptide, peptidomimetic, and organic synthetic combinatorial libraries.

Authors:  J Eichler; J R Appel; S E Blondelle; C T Dooley; B Dörner; J M Ostresh; E Pérez-Payá; C Pinilla; R A Houghten
Journal:  Med Res Rev       Date:  1995-11       Impact factor: 12.944

6.  Peptide libraries: determination of relative reaction rates of protected amino acids in competitive couplings.

Authors:  J M Ostresh; J H Winkle; V T Hamashin; R A Houghten
Journal:  Biopolymers       Date:  1994-12       Impact factor: 2.505

7.  "Libraries from libraries": chemical transformation of combinatorial libraries to extend the range and repertoire of chemical diversity.

Authors:  J M Ostresh; G M Husar; S E Blondelle; B Dörner; P A Weber; R A Houghten
Journal:  Proc Natl Acad Sci U S A       Date:  1994-11-08       Impact factor: 11.205

8.  Differential effects of protein-modifying reagents on receptor binding of opiate agonists and antagonists.

Authors:  G W Pasternak; H A Wilson; S H Snyder
Journal:  Mol Pharmacol       Date:  1975-05       Impact factor: 4.436

9.  Identification of antimicrobial peptides by using combinatorial libraries made up of unnatural amino acids.

Authors:  S E Blondelle; E Takahashi; P A Weber; R A Houghten
Journal:  Antimicrob Agents Chemother       Date:  1994-10       Impact factor: 5.191
  9 in total
  3 in total

1.  Mixture-based heterocyclic combinatorial positional scanning libraries: discovery of bicyclic guanidines having potent antifungal activities against Candida albicans and Cryptococcus neoformans.

Authors:  S E Blondelle; E Crooks; J M Ostresh; R A Houghten
Journal:  Antimicrob Agents Chemother       Date:  1999-01       Impact factor: 5.191

2.  On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds.

Authors:  Tina R White; Chad M Renzelman; Arthur C Rand; Taha Rezai; Cayla M McEwen; Vladimir M Gelev; Rushia A Turner; Roger G Linington; Siegfried S F Leung; Amit S Kalgutkar; Jonathan N Bauman; Yizhong Zhang; Spiros Liras; David A Price; Alan M Mathiowetz; Matthew P Jacobson; R Scott Lokey
Journal:  Nat Chem Biol       Date:  2011-09-25       Impact factor: 15.040

3.  Site-specific Labeling of a Protein Lysine Residue By Novel Kinetic Labeling Combinatorial Libraries.

Authors:  Allen Krantz; Arthur M Hanel; Ivona Strug; Andrzej Wilczynski; Jeremy J Wolff; Wolin Huang; Linda H Huang; Tina Settineri; Darren L Holmes; Margaret C Hardy; Dominique P Bridon
Journal:  Comput Struct Biotechnol J       Date:  2014-03-26       Impact factor: 7.271
  3 in total

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