Literature DB >> 9238010

The product of a thyroid hormone-responsive gene interacts with thyroid hormone receptors.

C C Thompson1, M C Bottcher.   

Abstract

Thyroid hormone is a critical mediator of central nervous system (CNS) development, acting through nuclear receptors to modulate the expression of specific genes. Transcription of the rat hairless (hr) gene is highly up-regulated by thyroid hormone in the developing CNS; we show here that hr is directly induced by thyroid hormone. By identifying proteins that interact with the hr gene product (Hr), we find that Hr interacts directly and specifically with thyroid hormone receptor (TR)-the same protein that regulates its expression. Unlike previously described receptor-interacting factors, Hr associates with TR and not with retinoic acid receptors (RAR, RXR). Hr can act as a transcriptional repressor, suggesting that its interaction with TR is part of a novel autoregulatory mechanism.

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Year:  1997        PMID： 9238010      PMCID： PMC22986          DOI： 10.1073/pnas.94.16.8527

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  32 in total

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Authors:  B Mellström; J R Naranjo; A Santos; A M Gonzalez; J Bernal
Journal:  Mol Endocrinol       Date:  1991-09

2.  The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors.

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Journal:  Cell       Date:  1991-06-28       Impact factor: 41.582

3.  Molecular basis of thyroid hormone regulation of myelin basic protein gene expression in rodent brain.

Authors:  A Farsetti; T Mitsuhashi; B Desvergne; J Robbins; V M Nikodem
Journal:  J Biol Chem       Date:  1991-12-05       Impact factor: 5.157

4.  Isolation and characterization of rat cDNA clones for two distinct thyroid hormone receptors.

Authors:  M B Murray; N D Zilz; N L McCreary; M J MacDonald; H C Towle
Journal:  J Biol Chem       Date:  1988-09-05       Impact factor: 5.157

5.  Depletion of L-3,5,3'-triiodothyronine and L-thyroxine in euthyroid calf serum for use in cell culture studies of the action of thyroid hormone.

Authors:  H H Samuels; F Stanley; J Casanova
Journal:  Endocrinology       Date:  1979-07       Impact factor: 4.736

6.  Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog.

Authors:  C C Thompson
Journal:  J Neurosci       Date:  1996-12-15       Impact factor: 6.167

7.  Binding of 3,5,3'-triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA protooncogenes: differences in the affinity of the alpha- and beta-forms for the acetic acid analog and failure of the human testis and kidney alpha-2 products to bind T3.

Authors:  P A Schueler; H L Schwartz; K A Strait; C N Mariash; J H Oppenheimer
Journal:  Mol Endocrinol       Date:  1990-02

8.  Role of endogenous retroviruses as mutagens: the hairless mutation of mice.

Authors:  J P Stoye; S Fenner; G E Greenoak; C Moran; J M Coffin
Journal:  Cell       Date:  1988-07-29       Impact factor: 41.582

9.  Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors.

Authors:  K Umesono; K K Murakami; C C Thompson; R M Evans
Journal:  Cell       Date:  1991-06-28       Impact factor: 41.582

Review 10.  The steroid and thyroid hormone receptor superfamily.

Authors:  R M Evans
Journal:  Science       Date:  1988-05-13       Impact factor: 47.728
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  42 in total

Review 1.  Tissue-specific actions of thyroid hormone: insights from animal models.

Authors:  G A Brent
Journal:  Rev Endocr Metab Disord       Date:  2000-01       Impact factor: 6.514

2.  Novel mechanism of nuclear receptor corepressor interaction dictated by activation function 2 helix determinants.

Authors:  Anna N Moraitis; Vincent Giguère; Catherine C Thompson
Journal:  Mol Cell Biol       Date:  2002-10       Impact factor: 4.272

3.  Thyroid hormone action on skin.

Authors:  Joshua D Safer
Journal:  Dermatoendocrinol       Date:  2011-07-01

4.  The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor.

Authors:  G B Potter; G M Beaudoin; C L DeRenzo; J M Zarach; S H Chen; C C Thompson
Journal:  Genes Dev       Date:  2001-10-15       Impact factor: 11.361

5.  Hairless triggers reactivation of hair growth by promoting Wnt signaling.

Authors:  Gerard M J Beaudoin; Jeanne M Sisk; Pierre A Coulombe; Catherine C Thompson
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-29       Impact factor: 11.205

6.  The thymus of the hairless rhino-j (hr/rh-j) mice.

Authors:  I San Jose; O García-Suárez; J Hannestad; R Cabo; L Gauna; J Represa; J A Vega
Journal:  J Anat       Date:  2001-04       Impact factor: 2.610

Review 7.  Amphibian metamorphosis.

Authors:  Donald D Brown; Liquan Cai
Journal:  Dev Biol       Date:  2007-03-23       Impact factor: 3.582

8.  Cerebellar defects in a mouse model of juvenile neuronal ceroid lipofuscinosis.

Authors:  Jill M Weimer; Jared W Benedict; Amanda L Getty; Charlie C Pontikis; Ming J Lim; Jonathan D Cooper; David A Pearce
Journal:  Brain Res       Date:  2009-02-20       Impact factor: 3.252

9.  Molecular basis for hair loss in mice carrying a novel nonsense mutation (Hrrh-R ) in the hairless gene (Hr).

Authors:  Y Liu; J P Sundberg; S Das; D Carpenter; K T Cain; E J Michaud; B H Voy
Journal:  Vet Pathol       Date:  2010-01       Impact factor: 2.221

10.  A novel mutation in Hr causes abnormal hair follicle morphogenesis in hairpoor mouse, an animal model for Marie Unna Hereditary Hypotrichosis.

Authors:  In Cheol Baek; Jeong Ki Kim; Kyu-Hyuk Cho; Dal-Sun Cha; Jae-Woo Cho; Jong Keun Park; Chang-Woo Song; Sungjoo Kim Yoon
Journal:  Mamm Genome       Date:  2009-06-10       Impact factor: 2.957
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