Literature DB >> 9237631

Reduction of thymine hydroperoxide by phospholipid hydroperoxide glutathione peroxidase and glutathione transferases.

Y Bao1, P Jemth, B Mannervik, G Williamson.   

Abstract

Thymine hydroperoxide (5-hydroperoxymethyluracil), a model compound representing products of oxidative damage to DNA, is a substrate for glutathione peroxidase and some isoforms of glutathione transferase. In this paper, we show that selenium-dependent human phospholipid hydroperoxide glutathione peroxidase (Se-PHGPx) exhibits about four orders of magnitude higher activity on thymine hydroperoxide than that of other human enzymes such as selenium-dependent glutathione peroxidase and various representatives of glutathione transferases. The results indicate that Se-PHGPx may be an important enzyme in repairing oxidatively damaged DNA.

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Year:  1997        PMID： 9237631     DOI： 10.1016/s0014-5793(97)00591-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  13 in total

1.  Preventive and reparative effects of isoleucine against copper-induced oxidative damage in primary fish enterocytes.

Authors:  Juan Zhao; Pei Wu; Weidan Jiang; Yang Liu; Jun Jiang; Yongan Zhang; Xiaoqiu Zhou; Lin Feng
Journal:  Fish Physiol Biochem       Date:  2017-01-28       Impact factor: 2.794

2.  The absence of cardiomyopathy is accompanied by increased activities of CAT, MnSOD and GST in long-term diabetes in rats.

Authors:  Svetlana Ivanović-Matić; Mirjana Mihailović; Svetlana Dinić; Vesna Martinović; Desanka Bogojević; Ilijana Grigorov; Goran Poznanović
Journal:  J Physiol Sci       Date:  2010-04-27       Impact factor: 2.781

3.  Induction of glutathione peroxidase 4 expression during enterocytic cell differentiation.

Authors:  Bodo Speckmann; Hans-Jürgen Bidmon; Antonio Pinto; Martin Anlauf; Helmut Sies; Holger Steinbrenner
Journal:  J Biol Chem       Date:  2011-01-20       Impact factor: 5.157

4.  2-Mercaptoethanol protects against DNA double-strand breaks after kidney ischemia and reperfusion injury through GPX4 upregulation.

Authors:  Daeun Moon; Babu J Padanilam; Hee-Seong Jang; Jinu Kim
Journal:  Pharmacol Rep       Date:  2022-08-22       Impact factor: 3.919

5.  Oxidative damage repair by glutamine in fish enterocytes.

Authors:  Kai Hu; Lin Feng; Weidan Jiang; Yang Liu; Jun Jiang; Shuhong Li; Xiaoqiu Zhou
Journal:  Fish Physiol Biochem       Date:  2014-04-29       Impact factor: 2.794

6.  Cellular responses to in vitro exposures to β-blocking pharmaceuticals in hard clams and Eastern oysters.

Authors:  Bushra Khan; Robert M Burgess; Sandra A Fogg; Mark G Cantwell; David R Katz; Kay T Ho
Journal:  Chemosphere       Date:  2018-07-27       Impact factor: 7.086

7.  A 72-h exposure study with eastern oysters (Crassostrea virginica) and the nanomaterial graphene oxide.

Authors:  Bushra Khan; Adeyemi S Adeleye; Robert M Burgess; Roxanna Smolowitz; Stephen M Russo; Kay T Ho
Journal:  Environ Toxicol Chem       Date:  2019-02-27       Impact factor: 3.742

8.  A glutathione peroxidase, intracellular peptidases and the TOR complexes regulate peptide transporter PEPT-1 in C. elegans.

Authors:  Jacqueline Benner; Hannelore Daniel; Britta Spanier
Journal:  PLoS One       Date:  2011-09-28       Impact factor: 3.240

Review 9.  Review article: the role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases.

Authors:  Aleksandra Piechota-Polanczyk; Jakub Fichna
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2014-05-06       Impact factor: 3.000

10.  Activation of Glutathione Peroxidase 4 as a Novel Anti-inflammatory Strategy.

Authors:  Cong Li; Xiaobing Deng; Xiaowen Xie; Ying Liu; José Pedro Friedmann Angeli; Luhua Lai
Journal:  Front Pharmacol       Date:  2018-10-03       Impact factor: 5.810
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