Literature DB >> 923732

Effect of propylthiouracil on intestinal tumor formation by azoxymethane in rats.

D V Singh, R L Campbell, Y N Lin, N D Nigro.   

Abstract

Treatment with propylthiouracil (PTU) resulted in a significant decrease in azoxymethane-induced intestinal tumors, total concentration of fecal bile acids as well as the fecal neutral steroids, cholesterol and coprostanol. Thus, a hypothyroid state induced by PTU treatment may affect intestinal carcinogenesis in this animal model by lowering the concentration of fecal bile acids and neutral steroids.

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Year:  1977        PMID： 923732     DOI： 10.1007/bf01918844

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  19 in total

1.  EFFECTS OF D- AND L-TRIIODOTHYRONINE AND OF PROPYLTHIOURACIL ON THE PRODUCTION OF BILE ACIDS IN THE RAT.

Authors:  O STRAND
Journal:  J Lipid Res       Date:  1963-07       Impact factor: 5.922

Review 2.  Cellular proliferation in carcinogenesis.

Authors:  W Oehlert
Journal:  Cell Tissue Kinet       Date:  1973-05

3.  Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N'-nitro-N-nitrosoguanidine in rats.

Authors:  T Narisawa; N E Magadia; J H Weisburger; E L Wynder
Journal:  J Natl Cancer Inst       Date:  1974-10       Impact factor: 13.506

4.  The effect of bile on the induction of experimental intestinal tumors in rats.

Authors:  C Chomchai; N Bhadrachari; N D Nigro
Journal:  Dis Colon Rectum       Date:  1974 May-Jun       Impact factor: 4.585

5.  A rat model for studying colonic cancer: effect of cholestyramine on induced tumors.

Authors:  N D Nigro; N Bhadrachari; C Chomchai
Journal:  Dis Colon Rectum       Date:  1973 Nov-Dec       Impact factor: 4.585

6.  Chemically induced mammary cancer in rats with altered thyroid function.

Authors:  W C Newman; R C Moon
Journal:  Cancer Res       Date:  1968-05       Impact factor: 12.701

7.  Importance of the fecal stream on the induction of colon tumors by azoxymethane in rats.

Authors:  R L Campbell; D V Singh; N D Nigro
Journal:  Cancer Res       Date:  1975-05       Impact factor: 12.701

8.  Control of cell growth. III. Direct mitogenic effect of thyroid hormones on an estrogen-dependent rat pituitary tumor cell line.

Authors:  W L Kirkland; J M Sorrentino; D A Sirbasku
Journal:  J Natl Cancer Inst       Date:  1976-06       Impact factor: 13.506

9.  Control of cell growth. II. Requirement of thyroid hormones for the in vivo estrogen-dependent growth of rat pituitary tumor cells.

Authors:  J M Sorrentino; W L Kirkland; D A Sirbasku
Journal:  J Natl Cancer Inst       Date:  1976-06       Impact factor: 13.506

10.  Carcinogenesis in the thyroidectomized rat.

Authors:  F BIELSCHOWSKY; W H HALL
Journal:  Br J Cancer       Date:  1953-09       Impact factor: 7.640
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