BACKGROUND: Intermittent claudication identifies persons at increased risk for death and disability. METHODS AND RESULTS: Using 38-year follow-up data for the original cohort in the Framingham Heart Study, we developed an intermittent claudication risk profile. Intermittent claudication occurred in a total of 381 men and women. Age, sex, serum cholesterol, hypertension, cigarette smoking, diabetes, and coronary heart disease were associated with an increased risk for claudication and were included in the profile. A pooled logistic regression model was used to compute the probability of intermittent claudication for specified levels of risk factors. CONCLUSIONS: The intermittent claudication risk profile allows physicians to identify high-risk individuals during a routine office visit and can be used to educate patients about modifiable risk factors, particularly smoking and blood pressure. Improved compliance with risk factor modification strategies may result in a beneficial impact on survival.
BACKGROUND: Intermittent claudication identifies persons at increased risk for death and disability. METHODS AND RESULTS: Using 38-year follow-up data for the original cohort in the Framingham Heart Study, we developed an intermittent claudication risk profile. Intermittent claudication occurred in a total of 381 men and women. Age, sex, serum cholesterol, hypertension, cigarette smoking, diabetes, and coronary heart disease were associated with an increased risk for claudication and were included in the profile. A pooled logistic regression model was used to compute the probability of intermittent claudication for specified levels of risk factors. CONCLUSIONS: The intermittent claudication risk profile allows physicians to identify high-risk individuals during a routine office visit and can be used to educate patients about modifiable risk factors, particularly smoking and blood pressure. Improved compliance with risk factor modification strategies may result in a beneficial impact on survival.
Authors: Bianca Lw Bendermacher; Joep Aw Teijink; Edith M Willigendael; Marie-Louise Bartelink; Harry R Büller; Ron Jg Peters; Jelis Boiten; Machteld Langenberg; Martin H Prins Journal: Br J Gen Pract Date: 2006-12 Impact factor: 5.386
Authors: Dominique Beaudry; Kenneth E Stone; Suzanne Wetherold; John Hemphill; Dat Do; John McClish; Robert Chilton Journal: Curr Atheroscler Rep Date: 2007-01 Impact factor: 5.113
Authors: Kelly P Downing; Kevin T Nead; Yoko Kojima; Themistocles Assimes; Lars Maegdefessel; Thomas Quertermous; John P Cooke; Nicholas J Leeper Journal: Vasc Med Date: 2013-12-09 Impact factor: 3.239
Authors: Emanuele Cecchi; Maria Grazia D'Alfonso; Marco Chiostri; Elena Parigi; Daniele Landi; Serafina Valente; Salvatore Mario Romano; Gian Franco Gensini; Cristina Giglioli Journal: High Blood Press Cardiovasc Prev Date: 2013-11-12