Literature DB >> 9235288

Essential biochemical design features of the fuel-sensing system in pancreatic beta-cells.

F M Matschinsky1, H W Collins.   

Abstract

The beta-cells of the pancreas control the blood levels of glucose and other nutrients by secreting insulin. They sense blood nutrient levels not by using a classical receptor-signaling system, but by detecting the products of nutrient metabolism. Mutations in this pathway can cause diabetes or hypoglycemia.

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Year:  1997        PMID： 9235288     DOI： 10.1016/s1074-5521(97)90068-5

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  5 in total

Review 1.  Secrets of the lac operon. Glucose hysteresis as a mechanism in dietary restriction, aging and disease.

Authors:  Charles V Mobbs; Jason W Mastaitis; Minhua Zhang; Fumiko Isoda; Hui Cheng; Kelvin Yen
Journal:  Interdiscip Top Gerontol       Date:  2007

2.  ADP-ribosylation factor 6 regulates insulin secretion through plasma membrane phosphatidylinositol 4,5-bisphosphate.

Authors:  John T R Lawrence; Morris J Birnbaum
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-29       Impact factor: 11.205

3.  Maternal rat diabetes mellitus deleteriously affects insulin sensitivity and Beta-cell function in the offspring.

Authors:  Abdel-Baset M Aref; Osama M Ahmed; Lobna A Ali; Margit Semmler
Journal:  J Diabetes Res       Date:  2013-08-12       Impact factor: 4.011

4.  Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice.

Authors:  Gaelle R Carrat; Ming Hu; Marie-Sophie Nguyen-Tu; Pauline Chabosseau; Kyle J Gaulton; Martijn van de Bunt; Afshan Siddiq; Mario Falchi; Matthias Thurner; Mickaël Canouil; Francois Pattou; Isabelle Leclerc; Timothy J Pullen; Matthew C Cane; Priyanka Prabhala; William Greenwald; Anke Schulte; Piero Marchetti; Mark Ibberson; Patrick E MacDonald; Jocelyn E Manning Fox; Anna L Gloyn; Philippe Froguel; Michele Solimena; Mark I McCarthy; Guy A Rutter
Journal:  Am J Hum Genet       Date:  2017-01-26       Impact factor: 11.025

5.  Autophagy-induced degradation of Notch1, achieved through intermittent fasting, may promote beta cell neogenesis: implications for reversal of type 2 diabetes.

Authors:  James J DiNicolantonio; Mark McCarty
Journal:  Open Heart       Date:  2019-05-22
  5 in total

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