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Literature DB >> 9234813

Role of vacuolating cytotoxin in gastritis due to Helicobacter pylori in gnotobiotic piglets.

K A Eaton¹, T L Cover, M K Tummuru, M J Blaser, S Krakowka.

Abstract

To investigate the role of the Helicobacter pylori cytotoxin in the pathogenesis of gastritis, gnotobiotic piglets were colonized with either toxigenic H. pylori or a nontoxigenic isogenic mutant. Only piglets given the toxigenic strain developed toxin-neutralizing antibodies (indicating that toxin is expressed in vivo), but there was no difference in bacterial colonization, epithelial vacuolation, or gastritis between the two groups of piglets.

Entities: Disease Species

Mesh：

Substances：

Year: 1997 PMID： 9234813 PMCID： PMC175490 DOI： 10.1128/iai.65.8.3462-3464.1997

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

19 in total

1. Cytotoxin production by Campylobacter pylori strains isolated from patients with peptic ulcers and from patients with chronic gastritis only.

Authors: N Figura; P Guglielmetti; A Rossolini; A Barberi; G Cusi; R A Musmanno; M Russi; S Quaranta
Journal: J Clin Microbiol Date: 1989-01 Impact factor: 5.948

2. Purification and characterization of the vacuolating toxin from Helicobacter pylori.

Authors: T L Cover; M J Blaser
Journal: J Biol Chem Date: 1992-05-25 Impact factor: 5.157

3. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration.

Authors: B J Marshall; J R Warren
Journal: Lancet Date: 1984-06-16 Impact factor: 79.321

4. Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology.

Authors: J E Crabtree; J D Taylor; J I Wyatt; R V Heatley; T M Shallcross; D S Tompkins; B J Rathbone
Journal: Lancet Date: 1991-08-10 Impact factor: 79.321

5. Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori.

Authors: J C Atherton; R M Peek; K T Tham; T L Cover; M J Blaser
Journal: Gastroenterology Date: 1997-01 Impact factor: 22.682

6. Gastritis associated with infection by Helicobacter pylori: comparative pathology in humans and swine.

Authors: T A Bertram; S Krakowka; D R Morgan
Journal: Rev Infect Dis Date: 1991 Jul-Aug

7. Campylobacter pylori virulence factors in gnotobiotic piglets.

Authors: K A Eaton; D R Morgan; S Krakowka
Journal: Infect Immun Date: 1989-04 Impact factor: 3.441

8. Chronic active gastritis due to Helicobacter pylori in immunized gnotobiotic piglets.

Authors: K A Eaton; S Krakowka
Journal: Gastroenterology Date: 1992-11 Impact factor: 22.682

9. Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains.

Authors: T L Cover; M K Tummuru; P Cao; S A Thompson; M J Blaser
Journal: J Biol Chem Date: 1994-04-08 Impact factor: 5.157

10. Cytotoxic activity in broth-culture filtrates of Campylobacter pylori.

Authors: R D Leunk; P T Johnson; B C David; W G Kraft; D R Morgan
Journal: J Med Microbiol Date: 1988-06 Impact factor: 2.472

20 in total

Review 1. VacA pores as portable portals for urea.

Authors: J L Merchant
Journal: J Clin Invest Date: 2001-09 Impact factor: 14.808

2. Murine splenocytes induce severe gastritis and delayed-type hypersensitivity and suppress bacterial colonization in Helicobacter pylori-infected SCID mice.

Authors: K A Eaton; S R Ringler; S J Danon
Journal: Infect Immun Date: 1999-09 Impact factor: 3.441

Role of vacuolating cytotoxin in gastritis due to Helicobacter pylori in gnotobiotic piglets.

1. Cytotoxin production by Campylobacter pylori strains isolated from patients with peptic ulcers and from patients with chronic gastritis only.

2. Purification and characterization of the vacuolating toxin from Helicobacter pylori.

3. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration.

4. Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology.

5. Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori.

6. Gastritis associated with infection by Helicobacter pylori: comparative pathology in humans and swine.

7. Campylobacter pylori virulence factors in gnotobiotic piglets.

8. Chronic active gastritis due to Helicobacter pylori in immunized gnotobiotic piglets.

9. Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains.

10. Cytotoxic activity in broth-culture filtrates of Campylobacter pylori.

Review 1. VacA pores as portable portals for urea.

2. Murine splenocytes induce severe gastritis and delayed-type hypersensitivity and suppress bacterial colonization in Helicobacter pylori-infected SCID mice.

3. Vacuolating cytotoxin of Helicobacter pylori plays a role during colonization in a mouse model of infection.

4. Polyphenols reduce gastritis induced by Helicobacter pylori infection or VacA toxin administration in mice.

5. Helicobacter pylori AlpA and AlpB bind host laminin and influence gastric inflammation in gerbils.

6. Comparison of the expressed porcine Vbeta and Jbeta repertoire of thymocytes and peripheral T cells.

7. In vivo complementation of ureB restores the ability of Helicobacter pylori to colonize.

8. Resistance of primary murine CD4+ T cells to Helicobacter pylori vacuolating cytotoxin.

9. Helicobacter pylori infection and disease: from humans to animal models.

10. Experimental infection of Mongolian gerbils with wild-type and mutant Helicobacter pylori strains.