Literature DB >> 9233829

Induction of differentiation and apoptosis by sodium selenite in human colonic carcinoma cells (HT29).

M S Stewart1, R L Davis, L P Walsh, B C Pence.   

Abstract

To explore the mechanism(s) by which selenium (Se) exerts its cancer chemopreventive activity, we studied the effect of selenite (0-100 microM) on cell growth, viability, differentiation, detachment, DNA fragmentation and apoptosis in human colonic carcinoma cells (HT29). Selenite (>5 microM) decreased cell growth, increased cell detachment and decreased intracellular levels of reduced glutathione (GSH), whereas >10 microM selenite induced cell differentiation and apoptosis. The chemopreventive effects of selenite may be related in part to the generation of reactive oxygen species (ROS) resulting from the reaction between selenite and GSH.

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Year:  1997        PMID： 9233829     DOI： 10.1016/s0304-3835(97)00212-7

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  8 in total

1.  [Relevance of the radioprotective effect of sodium selenite].

Authors:  H P Rodemann; T Hehr; M Bamberg
Journal:  Med Klin (Munich)       Date:  1999-10-15

2.  Responses of an American eel brain endothelial-like cell line to selenium deprivation and to selenite, selenate, and selenomethionine additions in different exposure media.

Authors:  Sophia R Bloch; John J Kim; Phuc H Pham; Peter V Hodson; Lucy E J Lee; Niels C Bols
Journal:  In Vitro Cell Dev Biol Anim       Date:  2017-09-22       Impact factor: 2.416

Review 3.  Chemopreventive mechanisms of selenium.

Authors:  G F Combs
Journal:  Med Klin (Munich)       Date:  1999-10-15

4.  Antioxidant supplement and long-term reduction of recurrent adenomas of the large bowel. A double-blind randomized trial.

Authors:  Luigina Bonelli; Matteo Puntoni; Beatrice Gatteschi; Paolo Massa; Guido Missale; Francesco Munizzi; Laura Turbino; Vincenzo Villanacci; Andrea De Censi; Paolo Bruzzi
Journal:  J Gastroenterol       Date:  2012-10-13       Impact factor: 7.527

5.  Relationship between reactive oxygen species and sodium-selenite-induced DNA damage in HepG2 cells.

Authors:  Yunfeng Zou; Piye Niu; Zhiyong Gong; Jin Yang; Jing Yuan; Tangchun Wu; Xuemin Chen
Journal:  Front Med China       Date:  2007-07-01

6.  Single-wall carbon nanohorns inhibited activation of microglia induced by lipopolysaccharide through blocking of Sirt3.

Authors:  Lihong Li; Jinqian Zhang; Yang Yang; Qiang Wang; Li Gao; Yanlong Yang; Tao Chang; Xingye Zhang; Guoan Xiang; Yongmei Cao; Zujin Shi; Ming Zhao; Guodong Gao
Journal:  Nanoscale Res Lett       Date:  2013-02-22       Impact factor: 4.703

Review 7.  Antitumor Effects of Selenium.

Authors:  Seung Jo Kim; Min Chul Choi; Jong Min Park; An Sik Chung
Journal:  Int J Mol Sci       Date:  2021-10-31       Impact factor: 5.923

8.  Single-walled carbon nanohorn (SWNH) aggregates inhibited proliferation of human liver cell lines and promoted apoptosis, especially for hepatoma cell lines.

Authors:  Jinqian Zhang; Qiang Sun; Jian Bo; Rui Huang; Mengran Zhang; Zhenglin Xia; Lili Ju; Guoan Xiang
Journal:  Int J Nanomedicine       Date:  2014-02-04
  8 in total

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