Literature DB >> 9232800

Synaptic signaling by nitric oxide.

J E Brenman1, D S Bredt.   

Abstract

Endogenous nitric oxide (NO) mediates certain aspects of synaptic plasticity and neurotoxicity associated with NMDA-type glutamate receptors. Neuronal NO synthase contains a modular protein-protein interaction motif, termed the PDZ domain, that links the synthase to a synaptic protein complex containing postsynaptic density protein PSD-95 and NMDA receptors. Characterization of this pathway has provided new insights into the role of NO in brain physiology and disease.

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Year:  1997        PMID： 9232800     DOI： 10.1016/s0959-4388(97)80065-7

Source DB:  PubMed          Journal:  Curr Opin Neurobiol        ISSN： 0959-4388            Impact factor:   6.627


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