Literature DB >> 9230691

Transforming growth factor-beta: the breaking open of a black box.

A Alevizopoulos1, N Mermod.   

Abstract

Transforming growth factor-beta (TGF-beta) and its related proteins regulate broad aspects of body development, including cell proliferation, differentiation, apoptosis and gene expression, in various organisms. Deregulated TGF-beta function has been causally implicated in the generation of human fibrotic disorders and in tumor progression. Nevertheless, the molecular mechanisms of TGF-beta action remained essentially unknown until recently. Here, we discuss recent progress in our understanding of the mechanism of TGF-beta signal transduction with respect to the regulation of gene expression, the control of cell phenotype and the potential usage of TGF-beta for the treatment of human diseases.

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Year:  1997        PMID： 9230691     DOI： 10.1002/bies.950190709

Source DB:  PubMed          Journal:  Bioessays        ISSN： 0265-9247            Impact factor:   4.345


  13 in total

1.  Platelet-derived growth factor is a principal inductive factormodulating mannose 6-phosphate/insulin-like growth factor-II receptorgene expression via a distal E-box in activated hepatic stellate cells.

Authors:  J A Weiner; A Chen; B H Davis
Journal:  Biochem J       Date:  2000-01-15       Impact factor: 3.857

2.  Dermatopontin interacts with transforming growth factor beta and enhances its biological activity.

Authors:  O Okamoto; S Fujiwara; M Abe; Y Sato
Journal:  Biochem J       Date:  1999-02-01       Impact factor: 3.857

3.  Parathyroid hormone-related peptide (PTHrP)-dependent and -independent effects of transforming growth factor beta (TGF-beta) on endochondral bone formation.

Authors:  R Serra; A Karaplis; P Sohn
Journal:  J Cell Biol       Date:  1999-05-17       Impact factor: 10.539

4.  A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest.

Authors:  G F Claassen; S R Hann
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-15       Impact factor: 11.205

5.  Transforming growth factor beta stimulation of colorectal cancer cell lines: type II receptor bypass and changes in adhesion molecule expression.

Authors:  M Ilyas; J A Efstathiou; J Straub; H C Kim; W F Bodmer
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-16       Impact factor: 11.205

6.  Apoptosis in nontumorous and neoplastic human pituitaries: expression of the Bcl-2 family of proteins.

Authors:  E Kulig; L Jin; X Qian; E Horvath; K Kovacs; L Stefaneanu; B W Scheithauer; R V Lloyd
Journal:  Am J Pathol       Date:  1999-03       Impact factor: 4.307

7.  A novel transcriptional factor with Ser/Thr kinase activity involved in the transforming growth factor (TGF)-beta signalling pathway.

Authors:  S Ohta; M Takeuchi; M Deguchi; T Tsuji; Y Gahara; K Nagata
Journal:  Biochem J       Date:  2000-09-01       Impact factor: 3.857

Review 8.  Beta-catenin--a linchpin in colorectal carcinogenesis?

Authors:  Newton Alexander Chiang Shuek Wong; Massimo Pignatelli
Journal:  Am J Pathol       Date:  2002-02       Impact factor: 4.307

9.  Hypoxia-generated superoxide induces the development of the adhesion phenotype.

Authors:  Nicole M Fletcher; Zhong L Jiang; Michael P Diamond; Husam M Abu-Soud; Ghassan M Saed
Journal:  Free Radic Biol Med       Date:  2008-05-15       Impact factor: 7.376

Review 10.  Mechanisms of Immune Escape and Resistance to Checkpoint Inhibitor Therapies in Mismatch Repair Deficient Metastatic Colorectal Cancers.

Authors:  Vito Amodio; Gianluca Mauri; Nicole M Reilly; Andrea Sartore-Bianchi; Salvatore Siena; Alberto Bardelli; Giovanni Germano
Journal:  Cancers (Basel)       Date:  2021-05-27       Impact factor: 6.639
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