Literature DB >> 9230504

Method for long-term intestinal access in the dog.

M Wilsson-Rahmberg1, O Jonsson.   

Abstract

A variety of devices have been used to establish long-term intestinal access in laboratory animals. Their use is complicated by infection, tissue reaction, and a frequent need for single housing to prevent implant damage. Intussuscepted nipple valves have long been used in the human field of surgery for various applications where there is a need to create a reservoir without leakage. With the use of the nipple valve it was possible to establish long-term intestinal access in dogs with minimal post-operative complications, no leakage and, because no foreign material was used, no complications due to tissue rejection. The advantages of a nipple valve over the similar technique of a straight stoma is less postoperative complications in the form of leakage as well as enhanced access due to the design of the nipple valve. Encouraging results prompted us to widen the use of nipple valves to 14 dogs in which it has been possible to establish long-term colonic or duodenal/ileal access at one or two sites. Nine of the dogs are still in use with duration of instrumentation for some animals exceeding 60 weeks. This method requires minimal maintenance, does not prevent group housing of instrumented dogs or outdoor activities nor does it compromise the quality of life for the animals.

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Year:  1997        PMID: 9230504     DOI: 10.1258/002367797780596356

Source DB:  PubMed          Journal:  Lab Anim        ISSN: 0023-6772            Impact factor:   2.471


  5 in total

1.  Influence of hydrodynamics and particle size on the absorption of felodipine in labradors.

Authors:  Annette Scholz; Bertil Abrahamsson; Steffen M Diebold; Edmund Kostewicz; Britta I Polentarutti; Anna-Lena Ungell; Jennifer B Dressman
Journal:  Pharm Res       Date:  2002-01       Impact factor: 4.200

2.  Alteration of the canine small-intestinal lactic acid bacterium microbiota by feeding of potential probiotics.

Authors:  Titta J K Manninen; Minna L Rinkinen; Shea S Beasley; Per E J Saris
Journal:  Appl Environ Microbiol       Date:  2006-10       Impact factor: 4.792

3.  Small intestinal permeability and serum folate and cobalamin absorption after surgical construction of permanent jejunal fistulas in laboratory beagle dogs.

Authors:  Rafael Frias; Jaana Harmoinen; Outi Laitinen-Vapaavuori; Thomas Spillmann; Satu Sankari; Elias Westermarck
Journal:  Comp Med       Date:  2010-10       Impact factor: 0.982

4.  Dominance of Lactobacillus acidophilus in the facultative jejunal Lactobacillus microbiota of fistulated beagles.

Authors:  Yurui Tang; Titta J K Manninen; Per E J Saris
Journal:  Appl Environ Microbiol       Date:  2012-07-27       Impact factor: 4.792

5.  Orally administered targeted recombinant Beta-lactamase prevents ampicillin-induced selective pressure on the gut microbiota: a novel approach to reducing antimicrobial resistance.

Authors:  Jaana Harmoinen; Silja Mentula; Matti Heikkilä; Michel van der Rest; Päivi J Rajala-Schultz; Curtis J Donskey; Rafael Frias; Pertti Koski; Nina Wickstrand; Hannele Jousimies-Somer; Elias Westermarck; Kai Lindevall
Journal:  Antimicrob Agents Chemother       Date:  2004-01       Impact factor: 5.191

  5 in total

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