Literature DB >> 9230312

Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling.

J Ericson1, P Rashbass, A Schedl, S Brenner-Morton, A Kawakami, V van Heyningen, T M Jessell, J Briscoe.   

Abstract

Distinct classes of motor neurons and ventral interneurons are generated by the graded signaling activity of Sonic hedgehog (Shh). Shh controls neuronal fate by establishing different progenitor cell populations in the ventral neural tube that are defined by the expression of Pax6 and Nkx2.2. Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain.

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Year:  1997        PMID： 9230312     DOI： 10.1016/s0092-8674(00)80323-2

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  276 in total

1.  Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development.

Authors:  C Kioussi; S O'Connell; L St-Onge; M Treier; A S Gleiberman; P Gruss; M G Rosenfeld
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-07       Impact factor: 11.205

2.  Combinatorial expression patterns of LIM-homeodomain and other regulatory genes parcellate developing thalamus.

Authors:  Y Nakagawa; D D O'Leary
Journal:  J Neurosci       Date:  2001-04-15       Impact factor: 6.167

3.  Quantitation of PAX6 and PAX6(5a) transcript levels in adult human lens, cornea, and monkey retina.

Authors:  W Zhang; K Cveklova; B Oppermann; M Kantorow; A Cvekl
Journal:  Mol Vis       Date:  2001-01-02       Impact factor: 2.367

4.  Constitutive expression of the neuron-restrictive silencer factor (NRSF)/REST in differentiating neurons disrupts neuronal gene expression and causes axon pathfinding errors in vivo.

Authors:  A J Paquette; S E Perez; D J Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  2000-10-24       Impact factor: 11.205

5.  Activation of the human PAX6 gene through the exon 1 enhancer by transcription factors SEF and Sp1.

Authors:  J B Zheng; Y H Zhou; T Maity; W S Liao; G F Saunders
Journal:  Nucleic Acids Res       Date:  2001-10-01       Impact factor: 16.971

6.  Defect of tyrosine hydroxylase-immunoreactive neurons in the brains of mice lacking the transcription factor Pax6.

Authors:  T Vitalis; O Cases; D Engelkamp; C Verney; D J Price
Journal:  J Neurosci       Date:  2000-09-01       Impact factor: 6.167

7.  Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding.

Authors:  H E Xu; M A Rould; W Xu; J A Epstein; R L Maas; C O Pabo
Journal:  Genes Dev       Date:  1999-05-15       Impact factor: 11.361

8.  Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

Authors:  Juliet A Williams; Oivin M Guicherit; Beatrice I Zaharian; Yin Xu; Ling Chai; Hynek Wichterle; Charlene Kon; Christine Gatchalian; Jeffery A Porter; Lee L Rubin; Frank Y Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-04       Impact factor: 11.205

9.  Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1.

Authors:  J P Incardona; J H Lee; C P Robertson; K Enga; R P Kapur; H Roelink
Journal:  Proc Natl Acad Sci U S A       Date:  2000-10-24       Impact factor: 11.205

10.  Specification of the mammalian cochlea is dependent on Sonic hedgehog.

Authors:  Martin M Riccomagno; Lenka Martinu; Michael Mulheisen; Doris K Wu; Douglas J Epstein
Journal:  Genes Dev       Date:  2002-09-15       Impact factor: 11.361
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