Literature DB >> 9230107

The peptide LSARLAF causes platelet secretion and aggregation by directly activating the integrin alphaIIbbeta3.

J M Derrick1, D B Taylor, R G Loudon, T K Gartner.   

Abstract

A novel peptide (designed to bind to alphaIIbbeta3) caused platelet aggregation and aggregation-independent secretion of the contents of alpha-granules in an alphaIIbbeta3-dependent fashion. The agonist peptide induced secretion in the presence of prostaglandin E1. In cell-free assays, alphaIIbbeta3 bound specifically to immobilized agonist peptide and the peptide enhanced the binding of fibrinogen to immobilized alphaIIbbeta3. The agonist peptide apparently activates alphaIIbbeta3 by directly inducing a conformational change in the receptor. This change activates the platelets and causes secretion in a manner independent of fibrinogen binding.

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Year:  1997        PMID： 9230107      PMCID： PMC1218561          DOI： 10.1042/bj3250309

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  32 in total

1.  Effect of calcium on the stability of the platelet membrane glycoprotein IIb-IIIa complex.

Authors:  L F Brass; S J Shattil; T J Kunicki; J S Bennett
Journal:  J Biol Chem       Date:  1985-07-05       Impact factor: 5.157

2.  Quantitation of membrane glycoprotein IIIa on intact human platelets using the monoclonal antibody, AP-3.

Authors:  P J Newman; R W Allen; R A Kahn; T J Kunicki
Journal:  Blood       Date:  1985-01       Impact factor: 22.113

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Authors:  H J Weiss; J Rogers
Journal:  Proc Soc Exp Biol Med       Date:  1973-01

4.  The amino-terminal one-third of alpha IIb defines the ligand recognition specificity of integrin alpha IIb beta 3.

Authors:  J C Loftus; C E Halloran; M H Ginsberg; L P Feigen; J A Zablocki; J W Smith
Journal:  J Biol Chem       Date:  1996-01-26       Impact factor: 5.157

5.  Hydropathic anti-complementarity of amino acids based on the genetic code.

Authors:  J E Blalock; E M Smith
Journal:  Biochem Biophys Res Commun       Date:  1984-05-31       Impact factor: 3.575

6.  Nonreversible loss of platelet aggregability induced by calcium deprivation.

Authors:  M B Zucker; R A Grant
Journal:  Blood       Date:  1978-09       Impact factor: 22.113

7.  Identification of two structurally and functionally distinct sites on human platelet membrane glycoprotein IIb-IIIa using monoclonal antibodies.

Authors:  R P McEver; E M Bennett; M N Martin
Journal:  J Biol Chem       Date:  1983-04-25       Impact factor: 5.157

8.  Studies with a murine monoclonal antibody that abolishes ristocetin-induced binding of von Willebrand factor to platelets: additional evidence in support of GPIb as a platelet receptor for von Willebrand factor.

Authors:  B S Coller; E I Peerschke; L E Scudder; C A Sullivan
Journal:  Blood       Date:  1983-01       Impact factor: 22.113

9.  A new murine monoclonal antibody reports an activation-dependent change in the conformation and/or microenvironment of the platelet glycoprotein IIb/IIIa complex.

Authors:  B S Coller
Journal:  J Clin Invest       Date:  1985-07       Impact factor: 14.808

10.  Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody.

Authors:  J S Bennett; J A Hoxie; S F Leitman; G Vilaire; D B Cines
Journal:  Proc Natl Acad Sci U S A       Date:  1983-05       Impact factor: 11.205
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  6 in total

1.  The beta3 subunit of the integrin alphaIIbbeta3 regulates alphaIIb-mediated outside-in signaling.

Authors:  Junling Liu; Carl W Jackson; Ralph A Gruppo; Lisa K Jennings; T Kent Gartner
Journal:  Blood       Date:  2005-02-08       Impact factor: 22.113

2.  Peptide LSARLAF induces integrin β3 dependent outside-in signaling in platelets.

Authors:  Haixia Niu; Zhenlu Xu; Ding Li; Lin Zhang; Kemin Wang; Donald B Taylor; Junling Liu; T Kent Gartner
Journal:  Thromb Res       Date:  2012-04-05       Impact factor: 3.944

3.  The heptapeptide LSARLAF mediates platelet activation through phospholipase Cgamma2 independently of glycoprotein IIb-IIIa.

Authors:  Andrew C Pearce; Peter Wonerow; Stuart J Marshall; Jon Frampton; T Kent Gartner; Steve P Watson
Journal:  Biochem J       Date:  2004-02-15       Impact factor: 3.857

4.  Targeted molecular dynamics reveals overall common conformational changes upon hybrid domain swing-out in beta3 integrins.

Authors:  Davide Provasi; Marta Murcia; Barry S Coller; Marta Filizola
Journal:  Proteins       Date:  2009-11-01

5.  Integrin αIIb-mediated PI3K/Akt activation in platelets.

Authors:  Haixia Niu; Xue Chen; Ralph A Gruppo; Ding Li; Yanhua Wang; Lin Zhang; Kemin Wang; Weiran Chai; Yueping Sun; Zhongren Ding; T Kent Gartner; Junling Liu
Journal:  PLoS One       Date:  2012-10-17       Impact factor: 3.240

6.  Inhibition of αIIbβ3 Ligand Binding by an αIIb Peptide that Clasps the Hybrid Domain to the βI Domain of β3.

Authors:  Wen Hwa Lee; Elisabeth Schaffner-Reckinger; Demokritos C Tsoukatos; Kelly Aylward; Vassilios Moussis; Vassilios Tsikaris; Paraskevi Trypou; Marion Egot; Dominique Baruch; Nelly Kieffer; Christilla Bachelot-Loza
Journal:  PLoS One       Date:  2015-09-02       Impact factor: 3.240
  6 in total

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