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Literature DB >> 9229109

Sox genes find their feet.

Abstract

The identification of the mammalian testis-determining factor, SRY, led to the description of a new class of genes encoding transcription factors, the SOX gene family. SOX proteins display properties of both classical transcription factors and architectural components of chromatin. The dynamic and diverse patterns of expression of SOX genes and analysis of mutations in humans, mice and Drosophila suggest that SOX factors play key roles in decisions of cell fate during diverse developmental processes.

Entities: Gene Species

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Year: 1997 PMID： 9229109 DOI： 10.1016/s0959-437x(97)80147-5

Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578

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Cited

128 in total

1. Campomelic dysplasia translocation breakpoints are scattered over 1 Mb proximal to SOX9: evidence for an extended control region.

Authors: D Pfeifer; R Kist; K Dewar; K Devon; E S Lander; B Birren; L Korniszewski; E Back; G Scherer
Journal: Am J Hum Genet Date: 1999-07 Impact factor: 11.025

2. Protein zero gene expression is regulated by the glial transcription factor Sox10.

Authors: R I Peirano; D E Goerich; D Riethmacher; M Wegner
Journal: Mol Cell Biol Date: 2000-05 Impact factor: 4.272

3. Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer.

Authors: A O Güre; E Stockert; M J Scanlan; R S Keresztes; D Jäger; N K Altorki; L J Old; Y T Chen
Journal: Proc Natl Acad Sci U S A Date: 2000-04-11 Impact factor: 11.205

Sox genes find their feet.

1. Campomelic dysplasia translocation breakpoints are scattered over 1 Mb proximal to SOX9: evidence for an extended control region.

2. Protein zero gene expression is regulated by the glial transcription factor Sox10.

3. Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer.

4. DNA binding by single HMG box model proteins.

5. The glial transcription factor Sox10 binds to DNA both as monomer and dimer with different functional consequences.

6. A direct role of SRY and SOX proteins in pre-mRNA splicing.

7. SpSoxB1 serves an essential architectural function in the promoter SpAN, a tolloid/BMP1-related gene.

8. Idiopathic weight reduction in mice deficient in the high-mobility-group transcription factor Sox8.

9. Lhx3 is required to maintain cancer cell development of high-grade oligodendroglioma.

10. SOX2 is a dose-dependent regulator of retinal neural progenitor competence.