Literature DB >> 9229011

Non-random deletions in human foamy virus long terminal repeat during viral infection.

J De Celis-Kosmas1, A Coronel, I Grigorian, R Emanoil-Ravier, J Tobaly-Tapiero.   

Abstract

We have characterized a new form of human foamy virus (HFV) non-random deleted long terminal repeat (LTR) sizing 1078-bp, deleted in its U3 region, sensitive to the viral transactivator and functional in an infectious proviral clone. Besides two known HFV LTRs of 1260-bp and 1123-bp, this LTR represents the smallest, designed S. Analysis of the LTR sequence shows the presence of short direct repeats surrounding the deletions, suggesting a mechanism generating deletion by misalignment of the growing strand during replication. Our data suggest that the deleted LTRs, preferentially associated with chronic viral infection, could be related with viral persistence.

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Year:  1997        PMID： 9229011     DOI： 10.1007/s007050050155

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


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  6 in total

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