Literature DB >> 9228943

Gas access to the active site of Ni-Fe hydrogenases probed by X-ray crystallography and molecular dynamics.

Y Montet, P Amara, A Volbeda, X Vernede, E C Hatchikian, M J Field, M Frey, J C Fontecilla-Camps.   

Abstract

The 2.54 A resolution structure of Ni-Fe hydrogenase has revealed the existence of hydrophobic channels connecting the molecular surface to the active site. A crystallographic analysis of xenon binding together with molecular dynamics simulations of xenon and H2 diffusion in the enzyme interior suggest that these channels serve as pathways for gas access to the active site.

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Year:  1997        PMID： 9228943     DOI： 10.1038/nsb0797-523

Source DB:  PubMed          Journal:  Nat Struct Biol        ISSN： 1072-8368


  55 in total

1.  Magnetization transfer from laser-polarized xenon to protons located in the hydrophobic cavity of the wheat nonspecific lipid transfer protein.

Authors:  C Landon; P Berthault; F Vovelle; H Desvaux
Journal:  Protein Sci       Date:  2001-04       Impact factor: 6.725

2.  Ligand diffusion in the catalase from Proteus mirabilis: a molecular dynamics study.

Authors:  P Amara; P Andreoletti; H M Jouve; M J Field
Journal:  Protein Sci       Date:  2001-10       Impact factor: 6.725

3.  Characterization of the hydrogen-deuterium exchange activities of the energy-transducing HupSL hydrogenase and H(2)-signaling HupUV hydrogenase in Rhodobacter capsulatus.

Authors:  P M Vignais; B Dimon; N A Zorin; M Tomiyama; A Colbeau
Journal:  J Bacteriol       Date:  2000-11       Impact factor: 3.490

4.  A single-amino-acid lid renders a gas-tight compartment within a membrane-bound transporter.

Authors:  Lina Salomonsson; Alex Lee; Robert B Gennis; Peter Brzezinski
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-02       Impact factor: 11.205

5.  Mechanistic insight into the blocking of CO diffusion in [NiFe]-hydrogenase mutants through multiscale simulation.

Authors:  Po-hung Wang; Jochen Blumberger
Journal:  Proc Natl Acad Sci U S A       Date:  2012-04-09       Impact factor: 11.205

6.  The crystal structure of an oxygen-tolerant hydrogenase uncovers a novel iron-sulphur centre.

Authors:  Johannes Fritsch; Patrick Scheerer; Stefan Frielingsdorf; Sebastian Kroschinsky; Bärbel Friedrich; Oliver Lenz; Christian M T Spahn
Journal:  Nature       Date:  2011-10-16       Impact factor: 49.962

7.  Structural basis for a [4Fe-3S] cluster in the oxygen-tolerant membrane-bound [NiFe]-hydrogenase.

Authors:  Yasuhito Shomura; Ki-Seok Yoon; Hirofumi Nishihara; Yoshiki Higuchi
Journal:  Nature       Date:  2011-10-16       Impact factor: 49.962

8.  Structural and gene expression analyses of uptake hydrogenases and other proteins involved in nitrogenase protection in Frankia.

Authors:  K H Richau; R L Kudahettige; P Pujic; N P Kudahettige; A Sellstedt
Journal:  J Biosci       Date:  2013-11       Impact factor: 1.826

Review 9.  Structure, function and biosynthesis of O₂-tolerant hydrogenases.

Authors:  Johannes Fritsch; Oliver Lenz; Bärbel Friedrich
Journal:  Nat Rev Microbiol       Date:  2013-02       Impact factor: 60.633

10.  Docking and migration of carbon monoxide in nitrogenase: the case for gated pockets from infrared spectroscopy and molecular dynamics.

Authors:  Leland B Gee; Igor Leontyev; Alexei Stuchebrukhov; Aubrey D Scott; Vladimir Pelmenschikov; Stephen P Cramer
Journal:  Biochemistry       Date:  2015-05-15       Impact factor: 3.162
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