PROBLEM: The paradigm of local suppression necessary to understand the survival of the fetal allograft is often compared with the host-tumor relationship. METHODS: We investigated two components of local immune suppression: placenta-induced immunosuppression, which is mediated at least in part by a soluble factor of low molecular weight that can induce anergy in lymphocytes, and interleukin-10 (IL-10). RESULTS: We show that enhancement of IL-10 production in the decidua and placenta after alloimmunization requires the presence of Asialo GM1+ cells. Placenta-induced immunosuppression is linked with defects in phosphorylation of some components of the T cell receptor. CONCLUSION: NK cells could be in fact regulatory cells pushing maternal immune response toward a Th2 profile, beneficial for fetal survival, or toward a Th1 type of immune response, which acts in synergy. Modulation of TcR may represent a new mechanism for maternal-fetal tolerance.
PROBLEM: The paradigm of local suppression necessary to understand the survival of the fetal allograft is often compared with the host-tumor relationship. METHODS: We investigated two components of local immune suppression: placenta-induced immunosuppression, which is mediated at least in part by a soluble factor of low molecular weight that can induce anergy in lymphocytes, and interleukin-10 (IL-10). RESULTS: We show that enhancement of IL-10 production in the decidua and placenta after alloimmunization requires the presence of Asialo GM1+ cells. Placenta-induced immunosuppression is linked with defects in phosphorylation of some components of the T cell receptor. CONCLUSION: NK cells could be in fact regulatory cells pushing maternal immune response toward a Th2 profile, beneficial for fetal survival, or toward a Th1 type of immune response, which acts in synergy. Modulation of TcR may represent a new mechanism for maternal-fetal tolerance.
Authors: Christopher D Heaney; Brittany Kmush; Ana Navas-Acien; Kevin Francesconi; Walter Gössler; Kerry Schulze; DeLisa Fairweather; Sucheta Mehra; Kenrad E Nelson; Sabra L Klein; Wei Li; Hasmot Ali; Saijuddin Shaikh; Rebecca D Merrill; Lee Wu; Keith P West; Parul Christian; Alain B Labrique Journal: Environ Res Date: 2015-07-15 Impact factor: 6.498
Authors: Matthew J Memoli; Hillery Harvey; David M Morens; Jeffery K Taubenberger Journal: Influenza Other Respir Viruses Date: 2012-11-21 Impact factor: 4.380
Authors: Madhuri S Salker; Jaya Nautiyal; Jennifer H Steel; Zoe Webster; Sandra Sućurović; Marilena Nicou; Yogesh Singh; Emma S Lucas; Keisuke Murakami; Yi-Wah Chan; Sean James; Yazan Abdallah; Mark Christian; B Anne Croy; Biserka Mulac-Jericevic; Siobhan Quenby; Jan J Brosens Journal: PLoS One Date: 2012-12-27 Impact factor: 3.240