Literature DB >> 9226994

Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist.

L J Bristow1, M S Kramer, J Kulagowski, S Patel, C I Ragan, G R Seabrook.   

Abstract

The discovery of a novel high-affinity and selective dopamine D4 receptor antagonist, L-745,870, and the results of clinical trials with this compound are reviewed. Despite several lines of evidence which suggest that a selective D4 receptor antagonist may be an effective antipsychotic agent with a lower propensity to induce extrapyramidal side-effects, L-745,870 was ineffective as an antipsychotic in humans.

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Year:  1997        PMID： 9226994     DOI： 10.1016/s0165-6147(97)01066-3

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  18 in total

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2.  The future of pharmacotherapy for schizophrenia.

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Review 3.  How antipsychotics work-from receptors to reality.

Authors:  Shitij Kapur; Ofer Agid; Romina Mizrahi; Ming Li
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4.  Neuregulin and dopamine modulation of hippocampal gamma oscillations is dependent on dopamine D4 receptors.

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Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-20       Impact factor: 11.205

5.  Synthesis and characterization of a series of chiral alkoxymethyl morpholine analogs as dopamine receptor 4 (D4R) antagonists.

Authors:  Jonathan O Witt; Andrea L McCollum; Miguel A Hurtado; Eric D Huseman; Daniel E Jeffries; Kayla J Temple; Hyekyung C Plumley; Anna L Blobaum; Craig W Lindsley; Corey R Hopkins
Journal:  Bioorg Med Chem Lett       Date:  2016-03-30       Impact factor: 2.823

6.  Clozapine's antipsychotic effects do not depend on blockade of 5-HT3 receptors.

Authors:  R F Squires; E Saederup
Journal:  Neurochem Res       Date:  1999-05       Impact factor: 3.996

7.  The dopamine D2, but not D3 or D4, receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice.

Authors:  R J Ralph; G B Varty; M A Kelly; Y M Wang; M G Caron; M Rubinstein; D K Grandy; M J Low; M A Geyer
Journal:  J Neurosci       Date:  1999-06-01       Impact factor: 6.167

8.  Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats.

Authors:  Jorge D Brioni; Robert B Moreland; Marlon Cowart; Gin C Hsieh; Andrew O Stewart; Petter Hedlund; Diana L Donnelly-Roberts; Masaki Nakane; James J Lynch; Teodozyi Kolasa; James S Polakowski; Mark A Osinski; Kennan Marsh; Karl-Erik Andersson; James P Sullivan
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-15       Impact factor: 11.205

9.  Serotonin receptor activation inhibits sodium current and dendritic excitability in prefrontal cortex via a protein kinase C-dependent mechanism.

Authors:  David B Carr; Donald C Cooper; Sasha L Ulrich; Nelson Spruston; D James Surmeier
Journal:  J Neurosci       Date:  2002-08-15       Impact factor: 6.167

10.  D2 receptor regulation of synaptic burst firing in prefrontal cortical pyramidal neurons.

Authors:  Yun Wang; Patricia S Goldman-Rakic
Journal:  Proc Natl Acad Sci U S A       Date:  2004-03-29       Impact factor: 11.205
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