| Literature DB >> 9226672 |
S Baykal1, H Usul, Y Aliyacioğlu, H Efe, S Duru.
Abstract
28 rats were studied. They were divided into four groups of 7 rats of each one-day control animals (Group A), seven-day control animals (Group B), one-day nerve growth factor (NGF)-treated animals (Group C) and seven-day NGF-treated animals (Group D). In all animals, the right sciatic nerve was explored and completely transected using microscissors under a microscope. In NGF-treated animals, NGF (0.1 mg/kg NGF) was injected subcutaneously. In control animals, there was a statistically significant decrease in AChE activity in the proximal stump of the transected sciatic nerve at 7-day measurements (p < 0.05). In the NGF-treated groups, mean AChE activity in the proximal stump of the transected sciatic nerve was decreased at the 7-day measurement. AChE activity difference between control and NGF-treated groups, measured on the 7th day, are statistically significant (p < 0.01). These results demonstrate the effect of NGF on the cholinergic system.Entities:
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Year: 1997 PMID： 9226672 DOI： 10.1007/bf01138196
Source DB: PubMed Journal: Neurosurg Rev ISSN： 0344-5607 Impact factor: 3.042