Literature DB >> 9226404

Chronic zolpidem treatment alters GABA(A) receptor mRNA levels in the rat cortex.

R A Holt1, A N Bateson, I L Martin.   

Abstract

The effect of chronic zolpidem treatment on the steady-state levels of gamma-aminobutyric acidA alpha1-6, beta1-3 and gamma1-3 subunit mRNAs in rat cortex has been investigated. Male Sprague-Dawley rats were injected once daily, for 7 or 14 days, with 15 mg/kg of zolpidem in sesame oil vehicle. The levels of the alpha4 and beta1 subunit mRNAs were significantly increased after 7 days of treatment and the level of alpha1 subunit mRNA was significantly decreased after 14 days of treatment, as determined by solution hybridization. These results are compared to the previously determined effects of an equivalent schedule of treatment with diazepam.

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Year:  1997        PMID： 9226404     DOI： 10.1016/s0014-2999(97)00168-4

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  9 in total

1.  The effects of zolpidem treatment and withdrawal on the in vitro expression of recombinant alpha1beta2gamma2s GABA(A) receptors expressed in HEK 293 cells.

Authors:  Josipa Vlainić; Maja Jazvinsćak Jembrek; Dubravka Svob Strac; Danka Pericić
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2010-07-23       Impact factor: 3.000

2.  Expression levels of the alpha4 subunit of the GABA(A) receptor in differentiated neuroblastoma cells are correlated with GABA-gated current.

Authors:  Xiangping Zhou; Sheryl S Smith
Journal:  Neuropharmacology       Date:  2009-03-11       Impact factor: 5.250

3.  Requirement of alpha5-GABAA receptors for the development of tolerance to the sedative action of diazepam in mice.

Authors:  Carolien van Rijnsoever; Marcus Täuber; Mohamed Khaled Choulli; Ruth Keist; Uwe Rudolph; Hanns Mohler; Jean Marc Fritschy; Florence Crestani
Journal:  J Neurosci       Date:  2004-07-28       Impact factor: 6.167

4.  Differential effects of short- and long-term zolpidem treatment on recombinant α1β2γ2s subtype of GABA(A) receptors in vitro.

Authors:  Josipa Vlainić; Maja Jazvinšćak Jembrek; Toni Vlainić; Dubravka Švob Strac; Danka Peričić
Journal:  Acta Pharmacol Sin       Date:  2012-08-27       Impact factor: 6.150

Review 5.  Neurosteroid regulation of GABA(A) receptors: Focus on the alpha4 and delta subunits.

Authors:  Sheryl S Smith; Hui Shen; Qi Hua Gong; Xiangping Zhou
Journal:  Pharmacol Ther       Date:  2007-04-21       Impact factor: 12.310

6.  The effects of repeated zolpidem treatment on tolerance, withdrawal-like symptoms, and GABAA receptor mRNAs profile expression in mice: comparison with diazepam.

Authors:  Brittany T Wright; Catherine F Gluszek; Scott A Heldt
Journal:  Psychopharmacology (Berl)       Date:  2014-02-15       Impact factor: 4.530

7.  Puberty, steroids and GABA(A) receptor plasticity.

Authors:  Sheryl S Smith; Chiye Aoki; Hui Shen
Journal:  Psychoneuroendocrinology       Date:  2009-12       Impact factor: 4.905

8.  Case report: Chronological symptom profile after cessation of overdose zolpidem in a patient with comorbid bipolar disorder-from anxiety, craving, paresthesia and influenza-like symptoms to seizures and hallucinations.

Authors:  Zi-Xin Mao; Xia Yang; Hui-Yao Wang; Wan-Jun Guo
Journal:  Front Psychiatry       Date:  2022-08-17       Impact factor: 5.435

9.  GABA(A) receptor α subunits differentially contribute to diazepam tolerance after chronic treatment.

Authors:  Christiaan H Vinkers; Ruud van Oorschot; Elsebet Ø Nielsen; James M Cook; Henrik H Hansen; Lucianne Groenink; Berend Olivier; Naheed R Mirza
Journal:  PLoS One       Date:  2012-08-13       Impact factor: 3.240
  9 in total

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