Literature DB >> 9226153

A metalloproteinase inhibitor prevents lethal acute graft-versus-host disease in mice.

K Hattori1, T Hirano, C Ushiyama, H Miyajima, N Yamakawa, T Ebata, Y Wada, S Ikeda, K Yoshino, M Tateno, K Oshimi, N Kayagaki, H Yagita, K Okumura.   

Abstract

Tumor necrosis factor (TNF) and Fas ligand (FasL) have been implicated in the pathogenesis of graft-versus-host disease (GVHD), which is a major complication after allogeneic bone marrow transplantation. We examined here the ameliorating effect of a metalloproteinase inhibitor (KB-R7785) that inhibits TNF-alpha and FasL release in a lethal acute GVHD model in mice. Administration of KB-R7785 into (BALB/c x C57BL/6) F1 that received C57BL/6 spleen cells markedly reduced the mortality and weight loss in association with minimal signs of GVHD pathology in the liver, intestine, and hematopoietic tissues. The ameliorating effect of KB-R7785 was superior to that of anti-TNF-alpha antibody. Our results suggest that KB-R7785 could be a potent therapeutic agent for GVHD.

Entities:  

Mesh：

Substances：

Year:  1997        PMID： 9226153

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  8 in total

1.  Host resistance to Listeria monocytogenes infection is enhanced but resistance to Staphylococcus aureus infection is reduced in acute graft-versus-host disease in mice.

Authors:  T Miura; D Mizuki; S Sasaki; S Hasegawa; H Sashinami; A Nakane
Journal:  Infect Immun       Date:  2000-07       Impact factor: 3.441

2.  Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking.

Authors:  A Sato; C Nishida; K Sato-Kusubata; M Ishihara; Y Tashiro; I Gritli; H Shimazu; S Munakata; H Yagita; K Okumura; Y Tsuda; Y Okada; A Tojo; H Nakauchi; S Takahashi; B Heissig; K Hattori
Journal:  Leukemia       Date:  2014-05-05       Impact factor: 11.528

3.  Protection from autoimmune diabetes and T-cell lymphoproliferation induced by FasL mutation are differentially regulated and can be uncoupled pharmacologically.

Authors:  Abdiaziz S Mohamood; Mehmet L Guler; Zuoxiang Xiao; Dongfeng Zheng; Allan Hess; Yi Wang; Hideo Yagita; Jonathan P Schneck; Abdel Rahim A Hamad
Journal:  Am J Pathol       Date:  2007-07       Impact factor: 4.307

4.  Increased serum levels of matrix metalloproteinase-9 in acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation.

Authors:  Kozo Tagami; Toshiaki Yujiri; Toru Takahashi; Nobuaki Kizuki; Yoshinori Tanaka; Noriyuki Mitani; Yukinori Nakamura; Koichi Ariyoshi; Toshihiko Ando; Toshikazu Gondo; Yukio Tanizawa
Journal:  Int J Hematol       Date:  2009-06-23       Impact factor: 2.490

Review 5.  Cytotoxic Pathways in Allogeneic Hematopoietic Cell Transplantation.

Authors:  Wei Du; Xuefang Cao
Journal:  Front Immunol       Date:  2018-12-19       Impact factor: 7.561

6.  Activation of invariant natural killer T cells stimulates adipose tissue remodeling via adipocyte death and birth in obesity.

Authors:  Jeu Park; Jin Young Huh; Jiyoung Oh; Jong In Kim; Sang Mun Han; Kyung Cheul Shin; Yong Geun Jeon; Sung Sik Choe; Jiyoung Park; Jae Bum Kim
Journal:  Genes Dev       Date:  2019-11-14       Impact factor: 11.361

7.  siRNA against CD40 delivered via a fungal recognition receptor ameliorates murine acute graft-versus-host disease.

Authors:  Beate Heissig; Yousef Salama; Masatoshi Tateno; Satoshi Takahashi; Koichi Hattori
Journal:  EJHaem       Date:  2022-05-06

8.  Soluble DNAM-1, as a Predictive Biomarker for Acute Graft-Versus-Host Disease.

Authors:  Minoru Kanaya; Kazuko Shibuya; Rei Hirochika; Miyoko Kanemoto; Kazuteru Ohashi; Masafumi Okada; Yukiko Wagatsuma; Yukiko Cho; Hiroshi Kojima; Takanori Teshima; Masahiro Imamura; Hisashi Sakamaki; Akira Shibuya
Journal:  PLoS One       Date:  2016-06-03       Impact factor: 3.240
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.