| Literature DB >> 9225609 |
Y Shao1, O Poobrasert, E J Kennelly, C K Chin, C T Ho, M T Huang, S A Garrison, G A Cordell.
Abstract
Two oligofurostanosides were isolated from the seeds of Asparagus officinalis L and their structures characterized as 3-O-[alpha-L-rhamnopyranosyl-(1-->2)-(alpha-L-rhamnopyranosyl- (1-->4))-beta-D-glucopyranosyl]-26-O-[beta-D-glucopyranosyl]-(25R) -22 alpha-methoxyfurost-5-ene-3 beta,26-diol(methyl protodioscin) and its corresponding 22 alpha-hydroxy analogue (protodioscin). The structural identification was performed using detailed analysis of 1H- and 13C-NMR spectra including two-dimensional NMR spectroscopy (COSY, HMQC, NOESY and HMBC), and chemical conversions. These two compounds have been shown to inhibit the growth of human leukemia HL-60 cells in culture and macromolecular synthesis in a dose-dependent manner. The inhibitory effect on DNA synthesis was found to be irreversible.Entities:
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Year: 1997 PMID： 9225609 DOI： 10.1055/s-2006-957667
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352