Literature DB >> 9225608

Betulinic acid: isolation from Triphyophyllum peltatum and Ancistrocladus heyneanus, antimalarial activity, and crystal structure of the benzyl ester.

G Bringmann1, W Saeb, L A Assi, G François, A S Sankara Narayanan, K Peters, E M Peters.   

Abstract

The known lupane-type triterpene betulinic acid (3) was isolated for the first time from Triphyophyllum peltatum and Ancistrocladus heyneanus. It was found to exhibit moderate to good in vitro antimalarial activity against asexual erythrocytic stages of the human malaria parasite Plasmodium falciparum. A first X-ray structure analysis succeeded after conversion into its benzyl ester 4.

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Year:  1997        PMID： 9225608     DOI： 10.1055/s-2006-957666

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  19 in total

1.  Studies on the anti-inflammatory, analgesic and antipyrexic activities of betulinic acid derived from Tetracera potatoria.

Authors:  Bukola Olunike Oyebanji; Adebowale Bernard Saba; Olayinka Ayotunde Oridupa
Journal:  Afr J Tradit Complement Altern Med       Date:  2013-11-02

2.  New betulinic acid derivatives as potent proteasome inhibitors.

Authors:  Keduo Qian; Sang-Yong Kim; Hsin-Yi Hung; Li Huang; Chin-Ho Chen; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem Lett       Date:  2011-07-26       Impact factor: 2.823

3.  Betulinic Acid Induces Apoptosis in Differentiated PC12 Cells Via ROS-Mediated Mitochondrial Pathway.

Authors:  Xi Wang; Xiaocheng Lu; Ronglan Zhu; Kaixin Zhang; Shuai Li; Zhongjun Chen; Lixin Li
Journal:  Neurochem Res       Date:  2017-01-25       Impact factor: 3.996

Review 4.  Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents.

Authors:  Reen-Yen Kuo; Keduo Qian; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Nat Prod Rep       Date:  2009-08-13       Impact factor: 13.423

5.  Lupane triterpenoids--betulin and betulinic acid derivatives induce apoptosis in tumor cells.

Authors:  Harish Kommera; Goran N Kaluđerović; Jutta Kalbitz; Reinhard Paschke
Journal:  Invest New Drugs       Date:  2009-12-04       Impact factor: 3.850

6.  Immunomodulatory effects of betulinic acid from the bark of white birch on mice.

Authors:  Jin-e Yi; Bozena Obminska-Mrukowicz; Li-yun Yuan; Hui Yuan
Journal:  J Vet Sci       Date:  2010-12       Impact factor: 1.672

7.  Cancer preventive agents 9. Betulinic acid derivatives as potent cancer chemopreventive agents.

Authors:  Kyoko Nakagawa-Goto; Koji Yamada; Masahiko Taniguchi; Harukuni Tokuda; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem Lett       Date:  2009-05-18       Impact factor: 2.823

8.  Diversity-oriented natural product platform identifies plant constituents targeting Plasmodium falciparum.

Authors:  Jin Zhang; John J Bowling; David Smithson; Julie Clark; Melissa R Jacob; Shabana I Khan; Babu L Tekwani; Michele Connelly; Vladimir Samoylenko; Mohamed A Ibrahim; Mohamed A Zaki; Mei Wang; John P Hester; Ying Tu; Cynthia Jeffries; Nathaniel Twarog; Anang A Shelat; Larry A Walker; Ilias Muhammad; R Kiplin Guy
Journal:  Malar J       Date:  2016-05-10       Impact factor: 2.979

9.  Investigation of Indian diospyros species for antiplasmodial properties.

Authors:  V S Satyanarayana Kantamreddi; Colin W Wright
Journal:  Evid Based Complement Alternat Med       Date:  2008-06       Impact factor: 2.629

10.  Screening and characterisation of antimicrobial properties of semisynthetic betulin derivatives.

Authors:  Shafiul Haque; Dorota A Nawrot; Sami Alakurtti; Leo Ghemtio; Jari Yli-Kauhaluoma; Päivi Tammela
Journal:  PLoS One       Date:  2014-07-17       Impact factor: 3.240
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