Literature DB >> 9224901

Cloning of Drosophila MCM homologs and analysis of their requirement during embryogenesis.

T T Su1, N Yakubovich, P H O'Farrell.   

Abstract

MCM (minichromosome maintenance) gene family of Saccharomyces cerevisiae encodes essential DNA replication factors that participate in the initiation of DNA replication. In addition, their localization to the nucleus in a mitosis-dependent manner fueled the hypothesis that MCMs also act to couple DNA replication to mitosis. We report the identification of a Drosophila gene family with extensive sequence identity to the MCM genes. Results from antibody injection experiments suggest that MCMs play an essential role in DNA replication during embryogenesis. Evolutionary conservation of MCM sequences and function in Drosophila could potentially facilitate studies of how initiation of DNA replication is regulated and coupled to mitosis during metazoan development.

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Year:  1997        PMID： 9224901      PMCID： PMC2753454          DOI： 10.1016/s0378-1119(97)00107-8

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  20 in total

1.  Parameters controlling transcriptional activation during early Drosophila development.

Authors:  B A Edgar; G Schubiger
Journal:  Cell       Date:  1986-03-28       Impact factor: 41.582

Review 2.  The role of MCM/P1 proteins in the licensing of DNA replication.

Authors:  J P Chong; P Thömmes; J J Blow
Journal:  Trends Biochem Sci       Date:  1996-03       Impact factor: 13.807

3.  A novel human Mcm protein: homology to the yeast replication protein Mis5 and chromosomal location.

Authors:  H P Holthoff; H Hameister; R Knippers
Journal:  Genomics       Date:  1996-10-01       Impact factor: 5.736

4.  Functional cDNA libraries from Drosophila embryos.

Authors:  N H Brown; F C Kafatos
Journal:  J Mol Biol       Date:  1988-09-20       Impact factor: 5.469

Review 5.  Using inhibitors to study embryogenesis.

Authors:  G Schubiger; B Edgar
Journal:  Methods Cell Biol       Date:  1994       Impact factor: 1.441

6.  Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor.

Authors:  Y Kubota; S Mimura; S Nishimoto; H Takisawa; H Nojima
Journal:  Cell       Date:  1995-05-19       Impact factor: 41.582

7.  Drosophila MCM protein complexes.

Authors:  T T Su; G Feger; P H O'Farrell
Journal:  Mol Biol Cell       Date:  1996-02       Impact factor: 4.138

8.  Cell proliferation and DNA replication defects in a Drosophila MCM2 mutant.

Authors:  J E Treisman; P J Follette; P H O'Farrell; G M Rubin
Journal:  Genes Dev       Date:  1995-07-15       Impact factor: 11.361

9.  Nuclear and cytoplasmic mitotic cycles continue in Drosophila embryos in which DNA synthesis is inhibited with aphidicolin.

Authors:  J W Raff; D M Glover
Journal:  J Cell Biol       Date:  1988-12       Impact factor: 10.539

10.  DNA polymerase alpha associated protein P1, a murine homolog of yeast MCM3, changes its intranuclear distribution during the DNA synthetic period.

Authors:  H Kimura; N Nozaki; K Sugimoto
Journal:  EMBO J       Date:  1994-09-15       Impact factor: 11.598
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  10 in total

1.  Exit from mitosis in Drosophila syncytial embryos requires proteolysis and cyclin degradation, and is associated with localized dephosphorylation.

Authors:  T T Su; F Sprenger; P J DiGregorio; S D Campbell; P H O'Farrell
Journal:  Genes Dev       Date:  1998-05-15       Impact factor: 11.361

2.  Drosophila ORC specifically binds to ACE3, an origin of DNA replication control element.

Authors:  R J Austin; T L Orr-Weaver; S P Bell
Journal:  Genes Dev       Date:  1999-10-15       Impact factor: 11.361

3.  Mutations of the Drosophila dDP, dE2F, and cyclin E genes reveal distinct roles for the E2F-DP transcription factor and cyclin E during the G1-S transition.

Authors:  R J Duronio; P C Bonnette; P H O'Farrell
Journal:  Mol Cell Biol       Date:  1998-01       Impact factor: 4.272

4.  Comparative RNA-sequencing analysis of ER-based HSP90 functions and signal pathways in Tribolium castaneum.

Authors:  Wenfeng Xiong; Mengfan Zhai; Xiaojuan Yu; Luting Wei; Jinjuan Mao; Juanjuan Liu; Jia Xie; Bin Li
Journal:  Cell Stress Chaperones       Date:  2017-07-05       Impact factor: 3.667

5.  The fertilization-induced DNA replication factor MCM6 of maize shuttles between cytoplasm and nucleus, and is essential for plant growth and development.

Authors:  Thomas Dresselhaus; Kanok-Orn Srilunchang; Dunja Leljak-Levanic; Daniela N Schreiber; Preeti Garg
Journal:  Plant Physiol       Date:  2006-01-11       Impact factor: 8.340

6.  Identification and expression analysis of minichromosome maintenance proteins in the silkworm, Bombyx mori.

Authors:  Kohji Yamamoto; Yoichi Aso; Hiroshi Fujii
Journal:  J Insect Sci       Date:  2010       Impact factor: 1.857

7.  Visualization of replication initiation and elongation in Drosophila.

Authors:  Julie M Claycomb; David M MacAlpine; James G Evans; Stephen P Bell; Terry L Orr-Weaver
Journal:  J Cell Biol       Date:  2002-10-28       Impact factor: 10.539

8.  CENP-meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila.

Authors:  J K Yucel; J D Marszalek; J R McIntosh; L S Goldstein; D W Cleveland; A V Philp
Journal:  J Cell Biol       Date:  2000-07-10       Impact factor: 10.539

9.  Chromosome association of minichromosome maintenance proteins in Drosophila mitotic cycles.

Authors:  T T Su; P H O'Farrell
Journal:  J Cell Biol       Date:  1997-10-06       Impact factor: 10.539

10.  Chromosome association of minichromosome maintenance proteins in Drosophila endoreplication cycles.

Authors:  T T Su; P H O'Farrell
Journal:  J Cell Biol       Date:  1998-02-09       Impact factor: 10.539
  10 in total

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