Literature DB >> 9224569

RNA as a drug target.

N D Pearson1, C D Prescott.   

Abstract

Historically, the pharmaceutical industry has focused on proteins, rather than nucleic acids, as drug targets. But recent advances in the fields of RNA synthesis, structure determination and therapeutic target identification make the systematic exploitation of RNA as a drug target a realistic goal.

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Substances：

Year:  1997        PMID： 9224569     DOI： 10.1016/s1074-5521(97)90192-7

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  10 in total

Review 1.  Aminoglycosides: activity and resistance.

Authors:  M P Mingeot-Leclercq; Y Glupczynski; P M Tulkens
Journal:  Antimicrob Agents Chemother       Date:  1999-04       Impact factor: 5.191

2.  Group I intron renders differential susceptibility of Candida albicans to Bleomycin.

Authors:  Prathiba Jayaguru; Malathi Raghunathan
Journal:  Mol Biol Rep       Date:  2006-11-07       Impact factor: 2.316

3.  The up-regulation of ferritin expression using a small-molecule ligand to the native mRNA.

Authors:  Jennifer D Tibodeau; Paige M Fox; Patricia A Ropp; Elizabeth C Theil; H Holden Thorp
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-28       Impact factor: 11.205

4.  Oligonucleotide directed misfolding of RNA inhibits Candida albicans group I intron splicing.

Authors:  Jessica L Childs; Matthew D Disney; Douglas H Turner
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-08       Impact factor: 11.205

5.  A novel CUG(exp)·MBNL1 inhibitor with therapeutic potential for myotonic dystrophy type 1.

Authors:  Amin Haghighat Jahromi; Lien Nguyen; Yuan Fu; Kali A Miller; Anne M Baranger; Steven C Zimmerman
Journal:  ACS Chem Biol       Date:  2013-03-20       Impact factor: 5.100

6.  Amikacin Inhibits miR-497 Maturation and Exerts Post-ischemic Neuroprotection.

Authors:  S Sinoy; S M Fayaz; K D Charles; V K Suvanish; Josef P Kapfhammer; G K Rajanikant
Journal:  Mol Neurobiol       Date:  2016-05-21       Impact factor: 5.590

7.  Inhibition of Escherichia coli RNase P by oligonucleotide directed misfolding of RNA.

Authors:  Jessica L Childs; Alex W Poole; Douglas H Turner
Journal:  RNA       Date:  2003-12       Impact factor: 4.942

8.  Cellular activity of Rev response element RNA targeting metallopeptides.

Authors:  Yan Jin; J A Cowan
Journal:  J Biol Inorg Chem       Date:  2007-03-14       Impact factor: 3.862

9.  Predicting candidate genomic sequences that correspond to synthetic functional RNA motifs.

Authors:  Uri Laserson; Hin Hark Gan; Tamar Schlick
Journal:  Nucleic Acids Res       Date:  2005-10-27       Impact factor: 16.971

Review 10.  Small molecules targeting viral RNA.

Authors:  Thomas Hermann
Journal:  Wiley Interdiscip Rev RNA       Date:  2016-06-16       Impact factor: 9.957
  10 in total

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