Literature DB >> 9223520

Poliovirus protein 2BC increases cytosolic free calcium concentrations.

R Aldabe1, A Irurzun, L Carrasco.   

Abstract

Poliovirus-infected cells undergo an increase in cytoplasmic calcium concentrations from the 4th h postinfection. The protein responsible for this effect was identified by the expression of different poliovirus nonstructural proteins in HeLa cells by using a recombinant vaccinia virus system. Synthesis of protein 2BC enhances cytoplasmic calcium concentrations in a manner similar to that observed in poliovirus-infected cells. To identify the regions in 2BC involved in modifying cytoplasmic calcium levels, several 2BC variants were generated. Regions present in both 2B and 2C are necessary to augment cellular free calcium levels. Therefore, in addition to inducing proliferation of membranous vesicles, poliovirus protein 2BC also alters cellular calcium homeostasis.

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Year:  1997        PMID： 9223520      PMCID： PMC191886     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  48 in total

1.  Does calcium ion binding control plant virus disassembly?

Authors:  A C Durham; D A Hendry; M B Von Wechmar
Journal:  Virology       Date:  1977-04       Impact factor: 3.616

2.  Genetic complementation among poliovirus mutants derived from an infectious cDNA clone.

Authors:  H D Bernstein; P Sarnow; D Baltimore
Journal:  J Virol       Date:  1986-12       Impact factor: 5.103

3.  Mitochondrial calcium uptake during infection of chicken embryo cells with Semliki Forest virus.

Authors:  E Peterhans; E Haenggeli; P Wild; R Wyler
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4.  Enhanced intracellular calcium concentration during poliovirus infection.

Authors:  A Irurzun; J Arroyo; A Alvarez; L Carrasco
Journal:  J Virol       Date:  1995-08       Impact factor: 5.103

5.  Leukotriene B4 and phosphatidic acid are calcium ionophores. Studies employing arsenazo III in liposomes.

Authors:  C N Serhan; J Fridovich; E J Goetzl; P B Dunham; G Weissmann
Journal:  J Biol Chem       Date:  1982-05-10       Impact factor: 5.157

6.  Activation of rotavirus RNA polymerase by calcium chelation.

Authors:  J Cohen; J Laporte; A Charpilienne; R Scherrer
Journal:  Arch Virol       Date:  1979       Impact factor: 2.574

7.  Calcium dependence of toxic cell death: a final common pathway.

Authors:  F A Schanne; A B Kane; E E Young; J L Farber
Journal:  Science       Date:  1979-11-09       Impact factor: 47.728

8.  Overexpression of the vaccinia virus A38L integral membrane protein promotes Ca2+ influx into infected cells.

Authors:  C M Sanderson; J E Parkinson; M Hollinshead; G L Smith
Journal:  J Virol       Date:  1996-02       Impact factor: 5.103

9.  Efficient cleavage of p220 by poliovirus 2Apro expression in mammalian cells: effects on vaccinia virus.

Authors:  R Aldabe; E Feduchi; I Novoa; L Carrasco
Journal:  Biochem Biophys Res Commun       Date:  1995-10-24       Impact factor: 3.575

Review 10.  Modification of membrane permeability by animal viruses.

Authors:  L Carrasco
Journal:  Adv Virus Res       Date:  1995       Impact factor: 9.937
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  42 in total

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Journal:  J Virol       Date:  2003-01       Impact factor: 5.103

Review 2.  Viroporins customize host cells for efficient viral propagation.

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Journal:  DNA Cell Biol       Date:  2013-08-14       Impact factor: 3.311

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Authors:  A Barco; L Carrasco
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

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Review 5.  Endoplasmic-reticulum calcium depletion and disease.

Authors:  Djalila Mekahli; Geert Bultynck; Jan B Parys; Humbert De Smedt; Ludwig Missiaen
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-06-01       Impact factor: 10.005

6.  Molecular Characterization of the Viroporin Function of Foot-and-Mouth Disease Virus Nonstructural Protein 2B.

Authors:  D P Gladue; E Largo; I de la Arada; V M Aguilella; A Alcaraz; J L R Arrondo; L G Holinka; E Brocchi; E Ramirez-Medina; E A Vuono; K A Berggren; C Carrillo; J L Nieva; M V Borca
Journal:  J Virol       Date:  2018-11-12       Impact factor: 5.103

7.  Enterovirus 71 2B Induces Cell Apoptosis by Directly Inducing the Conformational Activation of the Proapoptotic Protein Bax.

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8.  Blockade of the poliovirus-induced cytopathic effect in neural cells by monoclonal antibody against poliovirus or the human poliovirus receptor.

Authors:  Akiko Yanagiya; Qingmei Jia; Seii Ohka; Hitoshi Horie; Akio Nomoto
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9.  Identification of genes involved in the host response to enterovirus 71 infection.

Authors:  Shin-Ru Shih; Victor Stollar; Jing-Yi Lin; Shih-Cheng Chang; Guang-Wu Chen; Mei-Ling Li
Journal:  J Neurovirol       Date:  2004-10       Impact factor: 2.643

10.  Characterization of a membrane calcium pathway induced by rotavirus infection in cultured cells.

Authors:  J F Pérez; M C Ruiz; M E Chemello; F Michelangeli
Journal:  J Virol       Date:  1999-03       Impact factor: 5.103
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