Literature DB >> 9223251

Origin of genes.

W Gilbert1, S J de Souza, M Long.   

Abstract

We discuss two tests of the hypothesis that the first genes were assembled from exons. The hypothesis of exon shuffling in the progenote predicts that intron phases will be correlated so that exons will be an integer number of codons and predicts that the exons will be correlated with compact regions of polypeptide chain. These predictions have been tested on ancient conserved proteins (proteins without introns in prokaryotes but with introns in eukaryotes) and hold with high statistical significance. We conclude that introns are correlated with compact features of proteins 15-, 22-, or 30-amino acid residues long, as was predicted by "The Exon Theory of Genes."

Mesh：

Year:  1997        PMID： 9223251      PMCID： PMC33679          DOI： 10.1073/pnas.94.15.7698

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  13 in total

1.  On the antiquity of introns.

Authors:  W Gilbert; M Marchionni; G McKnight
Journal:  Cell       Date:  1986-07-18       Impact factor: 41.582

2.  Natural selection and the origin of jingwei, a chimeric processed functional gene in Drosophila.

Authors:  M Long; C H Langley
Journal:  Science       Date:  1993-04-02       Impact factor: 47.728

3.  Intron positions correlate with module boundaries in ancient proteins.

Authors:  S J de Souza; M Long; L Schoenbach; S W Roy; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-10       Impact factor: 11.205

4.  The exon theory of genes.

Authors:  W Gilbert
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1987

5.  Pseudogenes in yeast?

Authors:  G R Fink
Journal:  Cell       Date:  1987-04-10       Impact factor: 41.582

6.  Intron phase correlations and the evolution of the intron/exon structure of genes.

Authors:  M Long; C Rosenberg; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1995-12-19       Impact factor: 11.205

7.  Testing the exon theory of genes: the evidence from protein structure.

Authors:  A Stoltzfus; D F Spencer; M Zuker; J M Logsdon; W F Doolittle
Journal:  Science       Date:  1994-07-08       Impact factor: 47.728

8.  Genetic engineering in the Precambrian: structure of the chicken triosephosphate isomerase gene.

Authors:  D Straus; W Gilbert
Journal:  Mol Cell Biol       Date:  1985-12       Impact factor: 4.272

9.  Intron-exon splice junctions map at protein surfaces.

Authors:  C S Craik; S Sprang; R Fletterick; W J Rutter
Journal:  Nature       Date:  1982-09-09       Impact factor: 49.962

10.  Correlation of DNA exonic regions with protein structural units in haemoglobin.

Authors:  M Go
Journal:  Nature       Date:  1981-05-07       Impact factor: 49.962
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  61 in total

1.  Late changes in spliceosomal introns define clades in vertebrate evolution.

Authors:  B Venkatesh; Y Ning; S Brenner
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-31       Impact factor: 11.205

2.  Exon shuffling mimicked in cell culture.

Authors:  A A van Rijk; W W de Jong; H Bloemendal
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-06       Impact factor: 11.205

Review 3.  Microbial relatives of the seed storage proteins of higher plants: conservation of structure and diversification of function during evolution of the cupin superfamily.

Authors:  J M Dunwell; S Khuri; P J Gane
Journal:  Microbiol Mol Biol Rev       Date:  2000-03       Impact factor: 11.056

4.  A hierarchical approach to protein molecular evolution.

Authors:  L D Bogarad; M W Deem
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-16       Impact factor: 11.205

5.  Targeted modification and transportation of cellular proteins.

Authors:  P Colas; B Cohen; P Ko Ferrigno; P A Silver; R Brent
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-05       Impact factor: 11.205

6.  Mariner-like transposases are widespread and diverse in flowering plants.

Authors:  Cédric Feschotte; Susan R Wessler
Journal:  Proc Natl Acad Sci U S A       Date:  2001-12-26       Impact factor: 11.205

7.  Intron evolution as a population-genetic process.

Authors:  Michael Lynch
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-30       Impact factor: 11.205

Review 8.  Origins of gene, genetic code, protein and life: comprehensive view of life systems from a GNC-SNS primitive genetic code hypothesis.

Authors:  K Ikehara
Journal:  J Biosci       Date:  2002-03       Impact factor: 1.826

9.  Evolutionary relationships among Rel domains indicate functional diversification by recombination.

Authors:  I A Graef; J M Gastier; U Francke; G R Crabtree
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-08       Impact factor: 11.205

10.  Novel folded protein domains generated by combinatorial shuffling of polypeptide segments.

Authors:  L Riechmann; G Winter
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-29       Impact factor: 11.205
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