Literature DB >> 9222866

A new approach for the detection of type III hyperlipoproteinemia by RLP-cholesterol assay.

K Nakajima1, T Saito, A Tamura, M Suzuki, T Nakano, M Adachi, A Tanaka, N Tada, H Nakamura, T Murase.   

Abstract

Type III is a remnant hyperlipoproteinemia identified by the presence of beta-VLDL (remnant lipoprotein) as well as a genetic variant of apo E (apo E2/2). The RLP isolated from the serum of Type III patients by a new method we have developed, the RLPcholesterol assay, was identified as chylomicron and VLDL remnant. In addition, the RLP-C levels of the Type III patients were significantly higher than other hyperlipidemic patients with similar serum TG levels, while the ratio of TC/TG in RLP-C of both groups was not significantly different. The RLP-cholesterol assay appears to be useful for the screening and monitoring of Type III hyperlipoproteinemia when used in conjunction with the assays of serum TG level and genetic apo E isoform analysis.

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Year:  1994        PMID: 9222866     DOI: 10.5551/jat1994.1.30

Source DB:  PubMed          Journal:  J Atheroscler Thromb        ISSN: 1340-3478            Impact factor:   4.928


  3 in total

Review 1.  Postprandial lipoprotein metabolism: VLDL vs chylomicrons.

Authors:  Katsuyuki Nakajima; Takamitsu Nakano; Yoshiharu Tokita; Takeaki Nagamine; Akihiro Inazu; Junji Kobayashi; Hiroshi Mabuchi; Kimber L Stanhope; Peter J Havel; Mitsuyo Okazaki; Masumi Ai; Akira Tanaka
Journal:  Clin Chim Acta       Date:  2011-04-19       Impact factor: 3.786

2.  Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-B in young men and women.

Authors:  Kimber L Stanhope; Andrew A Bremer; Valentina Medici; Katsuyuki Nakajima; Yasuki Ito; Takamitsu Nakano; Guoxia Chen; Tak Hou Fong; Vivien Lee; Roseanne I Menorca; Nancy L Keim; Peter J Havel
Journal:  J Clin Endocrinol Metab       Date:  2011-08-17       Impact factor: 5.958

3.  Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans.

Authors:  Kimber L Stanhope; Jean Marc Schwarz; Nancy L Keim; Steven C Griffen; Andrew A Bremer; James L Graham; Bonnie Hatcher; Chad L Cox; Artem Dyachenko; Wei Zhang; John P McGahan; Anthony Seibert; Ronald M Krauss; Sally Chiu; Ernst J Schaefer; Masumi Ai; Seiko Otokozawa; Katsuyuki Nakajima; Takamitsu Nakano; Carine Beysen; Marc K Hellerstein; Lars Berglund; Peter J Havel
Journal:  J Clin Invest       Date:  2009-04-20       Impact factor: 14.808

  3 in total

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