OBJECTIVE: In this prospective study, we aimed to determine the efficacy of doxycycline and doxycycline plus ceftriaxone for the treatment of asymptomatic men with leukocytospermia. METHOD:Seventy men were included in this randomized and placebo-controlled study. White blood cell (WBC) concentrations were determined by peroxidase assay during the routine semen analysis. Twenty-four of 70 men with leukocytospermia were randomized as control group and administered placebo (group I), 25 received doxycyline alone (group II), and 21, doxycycline plus ceftriaxone (group III). Doxycycline, 100 mg, was given twice a day for ten days and ceftriaxone, 1 g, in two doses for only one day. After the treatment, semen analyses were repeated. RESULTS: After the treatment there was a significant decrease in WBC counts in groups II and III when compared with group I (P < .05). Both antibiotic regimens were found to be equally effective. However, the time needed for resolution of leukocytospermia (approximately 4 weeks) was similar between the control and treatment groups. CONCLUSION: Although both antibiotic regimens significantly, and equally, improved the white blood cell counts in men with leukocytospermia, they failed to treat the leukocytospermia, i.e., to bring the count below the limit of one million WBC/mL. Therefore, it is doubtful that antibiotic therapy should be recommended for asymptomatic men with leukocytospermia.
RCT Entities:
OBJECTIVE: In this prospective study, we aimed to determine the efficacy of doxycycline and doxycycline plus ceftriaxone for the treatment of asymptomatic men with leukocytospermia. METHOD: Seventy men were included in this randomized and placebo-controlled study. White blood cell (WBC) concentrations were determined by peroxidase assay during the routine semen analysis. Twenty-four of 70 men with leukocytospermia were randomized as control group and administered placebo (group I), 25 received doxycyline alone (group II), and 21, doxycycline plus ceftriaxone (group III). Doxycycline, 100 mg, was given twice a day for ten days and ceftriaxone, 1 g, in two doses for only one day. After the treatment, semen analyses were repeated. RESULTS: After the treatment there was a significant decrease in WBC counts in groups II and III when compared with group I (P < .05). Both antibiotic regimens were found to be equally effective. However, the time needed for resolution of leukocytospermia (approximately 4 weeks) was similar between the control and treatment groups. CONCLUSION: Although both antibiotic regimens significantly, and equally, improved the white blood cell counts in men with leukocytospermia, they failed to treat the leukocytospermia, i.e., to bring the count below the limit of one million WBC/mL. Therefore, it is doubtful that antibiotic therapy should be recommended for asymptomatic men with leukocytospermia.
Authors: Guntram Bezold; Joseph A Politch; Nancy B Kiviat; Jane M Kuypers; Hans Wolff; Deborah J Anderson Journal: Fertil Steril Date: 2007-04-11 Impact factor: 7.329
Authors: Jae Hung Jung; Myung Ha Kim; Jiye Kim; Soon Koo Baik; Sang-Baek Koh; Hyun Jun Park; Ju Tae Seo Journal: World J Mens Health Date: 2016-12-22 Impact factor: 5.400