Literature DB >> 922260

The antidysrhythmic aminosteroid, ORG 6001, reduces the ST-segment elevation produced by coronary occlusion in the dog.

R J Marshall, J R Parratt.   

Abstract

ST-segment elevation following temporary coronary artery occlusion was measured from nine epicardial leads in open-chest anaesthetized dogs. This was greatly reduced by the prior administration of the anti-dysrhythmic aminosteroid, ORG 6001. It is suggested that this effect is related either to a reduction in the extent and degree of myocardial ischaemia or to prevention of K+ egress from ischaemic cells.

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Year:  1977        PMID： 922260      PMCID： PMC1667497          DOI： 10.1111/j.1476-5381.1977.tb08421.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  11 in total

1.  Investigations to characterize a new anti-arrhythmic drug, ORG 6001 including a simple test for calcium antagonism.

Authors:  L A Salako; V Williams; J H Wittig
Journal:  Br J Pharmacol       Date:  1976-06       Impact factor: 8.739

2.  Antiarrhythmic, haemodynamic and metabolic effects of 3alpha-amino-5alpha-androstan-2beta-ol-17-one hydrochloride in greyhounds following acute coronary artery ligation.

Authors:  R J Marshall; J R Parratt
Journal:  Br J Pharmacol       Date:  1975-11       Impact factor: 8.739

3.  ST-segment potentials and mapping. Theory and experiments.

Authors:  H A Fozzard; D S DasGupta
Journal:  Circulation       Date:  1976-10       Impact factor: 29.690

4.  Changes in blood flow and oxygen consumption in normal and ischaemic regions of the myocardium following acute coronary artery ligation.

Authors:  R J Marshall; J R Parratt; I M Ledingham
Journal:  Cardiovasc Res       Date:  1974-03       Impact factor: 10.787

5.  Effects of various agents on regional ischemic myocardial injury: electrocardiographic analysis.

Authors:  R L Wendt; R C Canavan; R J Michalak
Journal:  Am Heart J       Date:  1974-04       Impact factor: 4.749

6.  Relationship between epicardial S-T segment changes and myocardial metabolism during acute coronary insufficiency.

Authors:  J Karlsson; G H Templeton; J T Willerson
Journal:  Circ Res       Date:  1973-06       Impact factor: 17.367

7.  The haemodynamic and metabolic effects of MG 8926, a prospective antidysrhythmic and antianginal agent.

Authors:  R J Marshall; J R Parratt
Journal:  Br J Pharmacol       Date:  1977-02       Impact factor: 8.739

8.  Magnetic determination of the relationship between the S-T segment shift and the injury current produced by coronary artery occlusion.

Authors:  D Cohen; L A Kaufman
Journal:  Circ Res       Date:  1975-03       Impact factor: 17.367

9.  Relation between infarct size and ventricular arrhythmia.

Authors:  R Roberts; A Husain; H D Ambos; G C Oliver; J R Cox; B E Sobel
Journal:  Br Heart J       Date:  1975-11

10.  Effects of verapamil on infarct size following experimental coronary occlusion.

Authors:  H J Smith; B N Singh; H D Nisbet; R M Norris
Journal:  Cardiovasc Res       Date:  1975-07       Impact factor: 10.787
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  3 in total

1.  Prostacyclin-induced changes in coronary blood flow and oxygen handling in the normal and acutely ischaemic canine myocardium.

Authors:  S J Coker; J R Parratt
Journal:  Basic Res Cardiol       Date:  1981 Jul-Aug       Impact factor: 17.165

2.  The effect of exaprolol (MG 8823) on epicardial ST-segment changes in a feline model of acute myocardial ischaemia.

Authors:  J R Parratt; E Udvary
Journal:  Br J Pharmacol       Date:  1983-09       Impact factor: 8.739

3.  The effects of disopyramide phosphate on early post-coronary artery ligation dysrhythmias and on epicardial ST-segment elevation in anaesthetized dogs.

Authors:  R J Marshall; J R Parratt
Journal:  Br J Pharmacol       Date:  1979-06       Impact factor: 8.739
  3 in total

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