Literature DB >> 9222539

Inhibition by heterologously-expressed P2Y2 nucleotide receptors of N-type calcium currents in rat sympathetic neurones.

A K Filippov1, T E Webb, E A Barnard, D A Brown.   

Abstract

The P2Y2 nucleotide receptor has previously been shown to stimulate phosphoinositide breakdown. We now show that, when P2Y2 receptors are heterologously expressed by cRNA injection into dissociated rat sympathetic neurones, activation of these receptors by uridine 5'-triphosphate (UTP) or adenosine 5'-triphosphate (ATP) inhibits the N-type voltage-gated calcium current by approximately 65%, with an IC50 of 0.5 microM. Thus, the same molecular species of nucleotide receptor can link to two different effector pathways.

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Year:  1997        PMID： 9222539      PMCID： PMC1564782          DOI： 10.1038/sj.bjp.0701270

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  11 in total

1.  Heteromeric assembly of GABA(B)R1 and GABA(B)R2 receptor subunits inhibits Ca(2+) current in sympathetic neurons.

Authors:  A K Filippov; A Couve; M N Pangalos; F S Walsh; D A Brown; S J Moss
Journal:  J Neurosci       Date:  2000-04-15       Impact factor: 6.167

Review 2.  P2 receptors: intracellular signaling.

Authors:  Laurie Erb; Zhongji Liao; Cheikh I Seye; Gary A Weisman
Journal:  Pflugers Arch       Date:  2006-04-04       Impact factor: 3.657

Review 3.  International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy.

Authors:  Maria P Abbracchio; Geoffrey Burnstock; Jean-Marie Boeynaems; Eric A Barnard; José L Boyer; Charles Kennedy; Gillian E Knight; Marta Fumagalli; Christian Gachet; Kenneth A Jacobson; Gary A Weisman
Journal:  Pharmacol Rev       Date:  2006-09       Impact factor: 25.468

Review 4.  Interaction of P2 purinergic receptors with cellular macromolecules.

Authors:  Laszlo Köles; Zoltan Gerevich; João Felipe Oliveira; Zoltan Sandor Zadori; Kerstin Wirkner; Peter Illes
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2007-12-19       Impact factor: 3.000

Review 5.  Nucleotide receptors in the nervous system. An abundant component using diverse transduction mechanisms.

Authors:  E A Barnard; J Simon; T E Webb
Journal:  Mol Neurobiol       Date:  1997-10       Impact factor: 5.590

6.  Regional expression of P2Y(4) receptors in the rat central nervous system.

Authors:  Xianmin Song; Wei Guo; Qiang Yu; Xiaofeng Liu; Zhenghua Xiang; Cheng He; Geoffrey Burnstock
Journal:  Purinergic Signal       Date:  2011-07-19       Impact factor: 3.765

7.  Dual coupling of heterologously-expressed rat P2Y6 nucleotide receptors to N-type Ca2+ and M-type K+ currents in rat sympathetic neurones.

Authors:  A K Filippov; T E Webb; E A Barnard; D A Brown
Journal:  Br J Pharmacol       Date:  1999-02       Impact factor: 8.739

8.  ATP and UTP responses of cultured rat aortic smooth muscle cells revisited: dominance of P2Y2 receptors.

Authors:  Rajendra Kumari; Gareth Goh; Leong L Ng; Michael R Boarder
Journal:  Br J Pharmacol       Date:  2003-11-03       Impact factor: 8.739

9.  Coupling of the nucleotide P2Y4 receptor to neuronal ion channels.

Authors:  Alexander K Filippov; Joseph Simon; Eric A Barnard; David A Brown
Journal:  Br J Pharmacol       Date:  2003-01       Impact factor: 8.739

10.  P2Y2 nucleotide receptors expressed heterologously in sympathetic neurons inhibit both N-type Ca2+ and M-type K+ currents.

Authors:  A K Filippov; T E Webb; E A Barnard; D A Brown
Journal:  J Neurosci       Date:  1998-07-15       Impact factor: 6.167
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