Literature DB >> 922249

The effects of intravenous anaesthetics on the cardiovascular system of the rabbit.

J C McGrath, J E MacKenzie.   

Abstract

1 A pithed rabbit preparation is described that allows selective stimulation of the vertebral outflows. 2 The responses to stimulation of sympathetic vasopressor fibres were blocked by hexamethonium and phentolamine but potentiated by cocaine, whereas the responses to stimulation of cardioaccelerator fibres were blocked by propranolol. 3 Ketamine, althesin and pentobarbitone enhanced the effects of noradrenaline and attenuated the effects of sympathetic nerve stimulation. Thiopentone enhanced the effects of both noradrenaline and sympathetic nerve stimulation. 4 In pithed rabbits a transient, dose-related cardiovascular depression was produced by each agent irrespective of whether vasomotor tone was present whereas in decerebrate rabbits the corresponding cardiovascular depression was longer lasting. 5 It is concluded that the cardiovascular depression produced by intravenous anaesthetics in intact rabbits is due to a combination of central and peripheral effects.

Entities:  

Mesh：

Substances：

Year:  1977        PMID： 922249      PMCID： PMC1667514          DOI： 10.1111/j.1476-5381.1977.tb08405.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  28 in total

1.  GENERAL ANESTHETIC AND OTHER PHARMACOLOGICAL PROPERTIES OF 2-(O-CHLOROPHENYL)-2-METHYLAMINO CYCLOHEXANONE HCL (CI-58L).

Authors:  D A MCCARTHY; G CHEN; D H KAUMP; C ENSOR
Journal:  J New Drugs       Date:  1965 Jan-Feb

2.  PHARMACOLOGIC EFFECTS OF CI-581, A NEW DISSOCIATIVE ANESTHETIC, IN MAN.

Authors:  E F DOMINO; P CHODOFF; G CORSSEN
Journal:  Clin Pharmacol Ther       Date:  1965 May-Jun       Impact factor: 6.875

3.  Hemodynamic changes during thiopental anesthesia in humans: cardiac output, stroke volume, total peripheral resistance, and intrathoracic blood volume.

Authors:  B ETSTEN; T H LI
Journal:  J Clin Invest       Date:  1955-03       Impact factor: 14.808

4.  The comparative pharmacology of the suprarenal medulla.

Authors:  G B WEST
Journal:  Q Rev Biol       Date:  1955-06       Impact factor: 4.875

5.  Mechanism of arterial spasm following intra-arterial injection of thiopentone.

Authors:  J H BURN; R HOBBS
Journal:  Lancet       Date:  1959-05-30       Impact factor: 79.321

6.  Comparative studies on the adrenergic neuro-hormonal control of resistance and capacitance blood vessels in the cat.

Authors:  S MELLANDER
Journal:  Acta Physiol Scand Suppl       Date:  1960

7.  General anesthesia and circulatory homeostasis.

Authors:  H L PRICE
Journal:  Physiol Rev       Date:  1960-04       Impact factor: 37.312

8.  Hemodynamic studies during thiopental sodium and nitrous oxide anesthesia in humans.

Authors:  E J FIELDMAN; R W RIDLEY; E H WOOD
Journal:  Anesthesiology       Date:  1955-07       Impact factor: 7.892

9.  Effects of general anesthetics on contractile responses of rabbit aortic strips.

Authors:  M L PRICE; H L PRICE
Journal:  Anesthesiology       Date:  1962 Jan-Feb       Impact factor: 7.892

10.  Effect of cocaine and related drugs on the uptake of noradrenaline by heart and spleen.

Authors:  E MUSCHOLL
Journal:  Br J Pharmacol Chemother       Date:  1961-06
View more
  8 in total

1.  The effects of ketamine on noradrenergic transmission and the response to noradrenaline in rat smooth muscle [proceedings].

Authors:  A J Byrne; T E Healy; D R Tomlinson
Journal:  Br J Pharmacol       Date:  1979-11       Impact factor: 8.739

2.  Blockade of vasopressor and vas deferens responses by alpha,beta-methylene ATP in the pithed rat.

Authors:  J M Bulloch; J C McGrath
Journal:  Br J Pharmacol       Date:  1988-05       Impact factor: 8.739

3.  A comparison of pre- and postsynaptic alpha-adrenergic effects of phenylephrine and tramazoline on blood vessels of the rabbit in vivo.

Authors:  A Steppeler; T Tanaka; K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-10       Impact factor: 3.000

4.  The cardiovascular effects of cyclopropane in the intact, decerebrate and pithed rabbit preparations.

Authors:  R L Hughes; J E MacKenzie
Journal:  Br J Pharmacol       Date:  1978-01       Impact factor: 8.739

5.  A comparison of the effects of pancuronium bromide and its monoquaternary analogue, ORG NC 45, on autonomic and somatic neurotransmission in the rat.

Authors:  J R Docherty; J C McGrath
Journal:  Br J Pharmacol       Date:  1980       Impact factor: 8.739

6.  Evidence for a physiological role of presynaptic alpha-adrenoceptors: modulation of noradrenaline release in the pithed rabbit.

Authors:  H Majewski; L Hedler; K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-12       Impact factor: 3.000

7.  Difference in the potency of alpha 2-adrenoceptor agonists and antagonists between the pithed rabbit and rat.

Authors:  J M Bulloch; J R Docherty; N A Flavahan; J C McGrath; C E McKean
Journal:  Br J Pharmacol       Date:  1987-07       Impact factor: 8.739

8.  Effects of ketamine on vascular smooth muscle function.

Authors:  B M Altura; B T Altura; A Carella
Journal:  Br J Pharmacol       Date:  1980-10       Impact factor: 8.739
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.