Literature DB >> 9219877

Astrocytes in the aged rat spinal cord fail to increase GFAP mRNA following sciatic nerve axotomy.

C J Kane1, T J Sims, S A Gilmore.   

Abstract

Aging in the brain is associated with specific changes in the astrocyte population. The present study establishes that similar changes occur in the aging spinal cord. The levels of glial fibrillary acidic protein (GFAP) mRNA were significantly increased 0.4-fold in aged 8- to 17-month-old rats compared to young 2-month-old rats. The ability of astrocytes in the aging spinal cord to respond to a non-invasive CNS injury was compared to young rats 4 days following sciatic nerve axotomy. The level of GFAP mRNA was significantly increased 0.5-fold in the young rats in response to axotomy. In contrast, the level of GFAP mRNA in aged rats did not increase following injury above that present in non-axotomized rats of the same age.

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Year:  1997        PMID： 9219877     DOI： 10.1016/s0006-8993(97)00359-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  6 in total

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Authors:  Megan Ryan Detloff; Lesley C Fisher; Violetta McGaughy; Erin E Longbrake; Phillip G Popovich; D Michele Basso
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Review 2.  The effects of age on pain sensitivity: preclinical studies.

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4.  Increased number of neurons in the cervical spinal cord of aged female rats.

Authors:  Enrique L Portiansky; Fabian Nishida; Claudio G Barbeito; Eduardo J Gimeno; Rodolfo G Goya
Journal:  PLoS One       Date:  2011-07-20       Impact factor: 3.240

Review 5.  Quantitative, structural and molecular changes in neuroglia of aging mammals: A review.

Authors:  Ennio Pannese
Journal:  Eur J Histochem       Date:  2021-06-23       Impact factor: 3.188

Review 6.  The Influence of Neuron-Extrinsic Factors and Aging on Injury Progression and Axonal Repair in the Central Nervous System.

Authors:  Theresa C Sutherland; Cédric G Geoffroy
Journal:  Front Cell Dev Biol       Date:  2020-03-25
  6 in total

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