Literature DB >> 9219343

Labeling proteins at high specific activity using N-succinimidyl 4-[18F](fluoromethyl) benzoate.

L Lang1, W C Eckelman.   

Abstract

High effective specific activity N-succinimidyl 4-[18F](fluoromethyl)benzoate was prepared using a reversed phase HPLC procedure. Reversed phase HPLC removed several additional impurities not removed by normal phase HPLC, thereby increasing the effective specific activity. Small amount (< 100 micrograms) of sensitive proteins such as erythropoietin can be labeled with this reagent in high yield without aggregation.

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Year:  1997        PMID: 9219343     DOI: 10.1016/s0969-8043(96)00151-0

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN: 0969-8043            Impact factor:   1.513


  6 in total

1.  N-Succinimidyl 4-[(18)F]-fluoromethylbenzoate-labeled dimeric RGD peptide for imaging tumor integrin expression.

Authors:  Weihua Li; Lixin Lang; Gang Niu; Ning Guo; Ying Ma; Dale O Kiesewetter; Baozhong Shen; Xiaoyuan Chen
Journal:  Amino Acids       Date:  2011-12-31       Impact factor: 3.520

Review 2.  Radiosyntheses using fluorine-18: the art and science of late stage fluorination.

Authors:  Erin L Cole; Megan N Stewart; Ryan Littich; Raphael Hoareau; Peter J H Scott
Journal:  Curr Top Med Chem       Date:  2014       Impact factor: 3.295

3.  MicroPET imaging of brain tumor angiogenesis with 18F-labeled PEGylated RGD peptide.

Authors:  Xiaoyuan Chen; Ryan Park; Yingping Hou; Vazgen Khankaldyyan; Ignacio Gonzales-Gomez; Michel Tohme; James R Bading; Walter E Laug; Peter S Conti
Journal:  Eur J Nucl Med Mol Imaging       Date:  2004-04-29       Impact factor: 9.236

Review 4.  PET designated flouride-18 production and chemistry.

Authors:  Orit Jacobson; Xiaoyuan Chen
Journal:  Curr Top Med Chem       Date:  2010       Impact factor: 3.295

5.  Optimized labeling of NOTA-conjugated octreotide with F-18.

Authors:  Peter Laverman; Christopher A D'Souza; Annemarie Eek; William J McBride; Robert M Sharkey; Wim J G Oyen; David M Goldenberg; Otto C Boerman
Journal:  Tumour Biol       Date:  2011-10-19

6.  Enhanced aqueous Suzuki-Miyaura coupling allows site-specific polypeptide 18F-labeling.

Authors:  Zhanghua Gao; Véronique Gouverneur; Benjamin G Davis
Journal:  J Am Chem Soc       Date:  2013-09-05       Impact factor: 15.419

  6 in total

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