Literature DB >> 9219001

Monosomy 22 in a mixed germ cell-sex cord-stromal tumor of the ovary.

F Speleman1, B Dermaut, C R De Potter, M Van Gele, N Van Roy, A De Paepe, G Laureys.   

Abstract

We report the cytogenetic findings in a case of mixed germ cell-sex cord-stromal tumor of the ovary in a 5-month-old girl. Monosomy 22 was observed as the sole karyotypic abnormality. This result was confirmed by comparative genomic hybridization, which revealed no additional chromosomal imbalances. This is the first observation of a chromosomal aberration in a mixed germ cell-sex cord-stromal tumor of the ovary. Monosomy 22 has been previously observed in granulosa cell tumors of the ovary. This could suggest a common pathogenetic pathway for both types of tumors.

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Year:  1997        PMID： 9219001

Source DB:  PubMed          Journal:  Genes Chromosomes Cancer        ISSN： 1045-2257            Impact factor:   5.006


  5 in total

1.  Mixed germ cell sex cord-stromal tumors of the testis and ovary. Morphological, immunohistochemical, and molecular genetic study of seven cases.

Authors:  Michal Michal; Tomas Vanecek; Radek Sima; Petr Mukensnabl; Ondrej Hes; Dmitry V Kazakov; Jozef Matoska; Anna Zuntova; Vladimir Dvorak; Alexander Talerman
Journal:  Virchows Arch       Date:  2006-03-15       Impact factor: 4.064

Review 2.  Unclassified mixed germ cell-sex cord-stromal tumor with multiple malignant cellular elements in a young woman: a case report and review of the literature.

Authors:  Shujie Pang; Lin Zhang; Yiquan Shi; Yixin Liu
Journal:  Int J Clin Exp Pathol       Date:  2014-07-15

3.  Promoter hypermethylation of MGMT, CDH1, RAR-beta and SYK tumour suppressor genes in granulosa cell tumours (GCTs) of ovarian origin.

Authors:  V S Dhillon; A R Young; S A Husain; M Aslam
Journal:  Br J Cancer       Date:  2004-02-23       Impact factor: 7.640

4.  Whole Genome Analysis of Ovarian Granulosa Cell Tumors Reveals Tumor Heterogeneity and a High-Grade TP53-Specific Subgroup.

Authors:  Joline Roze; Glen Monroe; Joachim Kutzera; Jolijn Groeneweg; Ellen Stelloo; Sterre Paijens; Hans Nijman; Hannah van Meurs; Luc van Lonkhuijzen; Jurgen Piek; Christianne Lok; Geertruida Jonges; Petronella Witteveen; René Verheijen; Gijs van Haaften; Ronald Zweemer
Journal:  Cancers (Basel)       Date:  2020-05-21       Impact factor: 6.639

5.  Spontaneous transformation of human granulosa cell tumours into an aggressive phenotype: a metastasis model cell line.

Authors:  Misa Imai; Miho Muraki; Kiyoshi Takamatsu; Hidekazu Saito; Motoharu Seiki; Yuji Takahashi
Journal:  BMC Cancer       Date:  2008-11-04       Impact factor: 4.430
  5 in total

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