The influence of alternative reinforcers on cocaine use and abuse: a brief review.

This report reviews experimental studies conducted with nonhuman and human subjects demonstrating that: a) cocaine's abuse liability is, in part, a function of its positive reinforcing effects, b) cocaine use is operant behavior, c) the degree of behavioral control that cocaine exerts as a reinforcer is malleable and dependent on environmental context, and d) increasing the availability of alternative, nondrug reinforcers can significantly disrupt the acquisition and maintenance of cocaine use and abuse. Implications of these observations for effective prevention and treatment of cocaine abuse are discussed.