OBJECTIVE: To describe the clinical features of reversible cognitive dysfunction. DESIGN: Prospective cohort study. SETTING: Acute geriatric inpatient units. PATIENTS: A random sample of consecutive acute admissions of patients over the age of 65 (N = 80). MAIN MEASUREMENTS: Serial assessments of mental state and cognitive function and observational data. OUTCOME MEASURE: Patients with more than five points of 20% improvement in Mini Mental State Examination following the most severely impaired assessment operationally designated 'reversible cognitive dysfunction'. The clinical features of those with RCD are compared with those with non-reversible cognitive dysfunction. MAIN RESULTS: Delusions, hallucinations, aggression, excitement, irritability and other 'active' symptoms were not commoner in RCD than in non-reversible cognitive dysfunction (non-RCD). By contrast, 'quiet' signs, such as plucking at bedclothes, poor attention, incoherent speech, abnormal associations, slow, vague thought and fluctuating mental state were more marked in RCD than in non-RCD. CONCLUSIONS: Reversible cognitive dysfunction is a quiet and unobtrusive disorder.
OBJECTIVE: To describe the clinical features of reversible cognitive dysfunction. DESIGN: Prospective cohort study. SETTING: Acute geriatric inpatient units. PATIENTS: A random sample of consecutive acute admissions of patients over the age of 65 (N = 80). MAIN MEASUREMENTS: Serial assessments of mental state and cognitive function and observational data. OUTCOME MEASURE: Patients with more than five points of 20% improvement in Mini Mental State Examination following the most severely impaired assessment operationally designated 'reversible cognitive dysfunction'. The clinical features of those with RCD are compared with those with non-reversible cognitive dysfunction. MAIN RESULTS: Delusions, hallucinations, aggression, excitement, irritability and other 'active' symptoms were not commoner in RCD than in non-reversible cognitive dysfunction (non-RCD). By contrast, 'quiet' signs, such as plucking at bedclothes, poor attention, incoherent speech, abnormal associations, slow, vague thought and fluctuating mental state were more marked in RCD than in non-RCD. CONCLUSIONS: Reversible cognitive dysfunction is a quiet and unobtrusive disorder.
Authors: Sharon K Inouye; Ying Zhang; Ling Han; Linda Leo-Summers; Richard Jones; Edward Marcantonio Journal: J Gen Intern Med Date: 2006-09-11 Impact factor: 5.128
Authors: Esteban Sepulveda; Maeve Leonard; Jose G Franco; Dimitrios Adamis; Geraldine McCarthy; Colum Dunne; Paula T Trzepacz; Ana M Gaviria; Joan de Pablo; Elisabet Vilella; David J Meagher Journal: Alzheimers Dement (Amst) Date: 2016-12-01