Literature DB >> 9215375

Combined surgery and radiation therapy for squamous cell carcinoma of the hypopharynx.

D H Kraus1, M J Zelefsky, H A Brock, J Huo, L B Harrison, J P Shah.   

Abstract

Squamous cell carcinoma of the hypopharynx remains a highly lethal disease. This article documents our experience with 132 patients undergoing surgical management of squamous cell carcinoma of the hypopharynx, of whom 80% received postoperative radiation therapy. Local-regional control was obtained in 61% of the patients. Five-year overall and disease-free survival rates were 30% and 41%, respectively. Prognosis was better in patients with limited disease: local disease permitting larynx-sparing surgery, N0/N1 clinical neck, and stage I/II/III disease. Cancer of the hypopharynx remains an aggressive entity associated with poor prognosis. Novel strategies stressing improved local-regional control with prevention of distant metastasis are warranted.

Entities:  

Mesh：

Year:  1997        PMID： 9215375     DOI： 10.1016/S0194-59989770240-7

Source DB:  PubMed          Journal:  Otolaryngol Head Neck Surg        ISSN： 0194-5998            Impact factor:   3.497


  13 in total

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