Literature DB >> 9215322

Expression of estrogen receptor-beta in human breast tumors.

H Dotzlaw1, E Leygue, P H Watson, L C Murphy.   

Abstract

The expression of a recently described novel estrogen receptor, ER-beta, was detected in several human breast tumor biopsy samples and several human breast epithelial cell lines using reverse transcription and polymerase chain reaction (RT-PCR) analysis. Cloning and sequencing of the PCR product from a breast tumor confirmed the identity of the sequence with that of the ER-beta mRNA previously reported in human testis. The expression of ER-beta was not correlated with that of ER-alpha, and both ER-alpha positive and ER-alpha negative cell lines expressed ER-beta mRNA. However, some breast tumors and some cell lines coexpress ER-beta and ER-alpha mRNA. Our data support a possible role for ER-beta in human breast cancer.

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Year:  1997        PMID： 9215322     DOI： 10.1210/jcem.82.7.4212

Source DB:  PubMed          Journal:  J Clin Endocrinol Metab        ISSN： 0021-972X            Impact factor:   5.958


  31 in total

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Authors:  S Saji; E V Jensen; S Nilsson; T Rylander; M Warner; J A Gustafsson
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-04       Impact factor: 11.205

5.  Quantitative histomorphometric analysis of gonadal steroid receptor distribution in the normal human endometrium through the menstrual cycle.

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6.  Expression of estrogen receptors alpha and beta in human meningiomas.

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7.  Expression and prognostic value of estrogen receptor β in patients with triple-negative and triple-positive breast cancer.

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Review 8.  Antiestrogens--tamoxifen, SERMs and beyond.

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Journal:  Invest New Drugs       Date:  1999       Impact factor: 3.850

Review 9.  Estrogen receptor-beta and breast cancer: translating biology into clinical practice.

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Journal:  Steroids       Date:  2012-03-29       Impact factor: 2.668

10.  Estrogen receptor beta isoform-specific induction of transforming growth factor beta-inducible early gene-1 in human osteoblast cells: an essential role for the activation function 1 domain.

Authors:  John R Hawse; Malayannan Subramaniam; David G Monroe; Amanda H Hemmingsen; James N Ingle; Sundeep Khosla; Merry Jo Oursler; Thomas C Spelsberg
Journal:  Mol Endocrinol       Date:  2008-05-15
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