| Literature DB >> 9214741 |
J T Weber1, M F O'Connor, K Hayataka, N Colson, R Medora, E B Russo, K K Parker.
Abstract
Parthenolide displaces [3H]ketanserin from 5HT2A receptors from rat and rabbit brain and cloned 5HT2A receptors. Ki's are in the 100-250 microM range. These results suggest that parthenolide may be a low-affinity antagonist at 5HT receptors; it is unlikely that the entire mechanism of action can be explained by its modest 5HT2A receptor affinity.Entities:
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Year: 1997 PMID： 9214741 DOI： 10.1021/np960644d
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050