Literature DB >> 9214732

Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia.

T S Wu1, M J Liou, C S Kuoh, C M Teng, T Nagao, K H Lee.   

Abstract

Two related 1H-2,3,3a,8b-tetrahydrocyclopenta[b]benzofurans, aglafolin (1a) and rocaglamide (2), isolated from the stems of Aglaia elliptifolia, showed significant cytotoxicity in six cancer cell lines. Aglafolin (1a) was also found to completely block platelet aggregation caused by arachidonic acid and platelet-activating factor at 100 microM and 2 ng/mL, respectively.

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Year:  1997        PMID： 9214732     DOI： 10.1021/np970163+

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  6 in total

Review 1.  Potential of plant-derived natural products in the treatment of leukemia and lymphoma.

Authors:  David M Lucas; Patrick C Still; Lynette Bueno Pérez; Michael R Grever; A Douglas Kinghorn
Journal:  Curr Drug Targets       Date:  2010-07       Impact factor: 3.465

2.  Cytotoxic flavaglines and bisamides from Aglaia edulis.

Authors:  Soyoung Kim; Young-Won Chin; Bao-Ning Su; Soedarsono Riswan; Leonardus B S Kardono; Johar J Afriastini; Heebyung Chai; Norman R Farnsworth; Geoffrey A Cordell; Steven M Swanson; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2006-12       Impact factor: 4.050

3.  Hierarchical Virtual Screening Based on Rocaglamide Derivatives to Discover New Potential Anti-Skin Cancer Agents.

Authors:  Igor V F Dos Santos; Rosivaldo S Borges; Guilherme M Silva; Lúcio R de Lima; Ruan S Bastos; Ryan S Ramos; Luciane B Silva; Carlos H T P da Silva; Cleydson B R Dos Santos
Journal:  Front Mol Biosci       Date:  2022-06-02

4.  The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo.

Authors:  David M Lucas; Ryan B Edwards; Gerard Lozanski; Derek A West; Jungook D Shin; Melissa A Vargo; Melanie E Davis; Darlene M Rozewski; Amy J Johnson; Bao-Ning Su; Virginia M Goettl; Nyla A Heerema; Thomas S Lin; Amy Lehman; Xiaoli Zhang; David Jarjoura; David J Newman; John C Byrd; A Douglas Kinghorn; Michael R Grever
Journal:  Blood       Date:  2009-02-03       Impact factor: 22.113

Review 5.  Progress in the total synthesis of rocaglamide.

Authors:  Xiao-Hua Cai; Bing Xie; Hui Guo
Journal:  ISRN Org Chem       Date:  2011-04-04

6.  Synthesis of cis-Oriented Vicinal Diphenylethylenes through a Lewis Acid-Promoted Annulation of Oxotriphenylhexanoates.

Authors:  Martin Kamlar; Elin Henriksson; Ivana Císařová; Marcus Malo; Henrik Sundén
Journal:  J Org Chem       Date:  2021-06-17       Impact factor: 4.354
  6 in total

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