Literature DB >> 921408

Hepatic oxidative drug metabolism in rats with experimental renal failure.

A P Van Peer, F M Belpaire.   

Abstract

The activity of the drug-oxidizing system was investigated in liver homogenates of control and uraemic rats. Acute renal failure was achieved by ligation of the ureters or by intravenous injection of uranyl nitrate. In the uraemic state the concentration of cytochrome P450 and the activity of aniline hydroxylase were not significantly changed, but the activity of aminopyrine N-demethylase was significantly decreased. In rats the hepatic oxidizing enzymes are not induced by the uraemic state, in contrast to what has been suggested in man.

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Year:  1977        PMID： 921408

Source DB:  PubMed          Journal:  Arch Int Pharmacodyn Ther        ISSN： 0003-9780


  9 in total

1.  Downregulation of hepatic acetylation of drugs in chronic renal failure.

Authors:  Emilie Simard; Judith Naud; Josée Michaud; Francois A Leblond; Alain Bonnardeaux; Chantal Guillemette; Edith Sim; Vincent Pichette
Journal:  J Am Soc Nephrol       Date:  2008-04-16       Impact factor: 10.121

2.  Reduced hepatic synthesis of calcidiol in uremia.

Authors:  Josée Michaud; Judith Naud; Denis Ouimet; Christian Demers; Jean-Luc Petit; Francois A Leblond; Alain Bonnardeaux; Marielle Gascon-Barré; Vincent Pichette
Journal:  J Am Soc Nephrol       Date:  2010-07-01       Impact factor: 10.121

3.  Proceedings of the British Pharmacological Society. Leeds, 12th-14th July 1989. Abstracts.

Authors: 
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

4.  Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction.

Authors:  Kengo Hamamura; Naoya Matsunaga; Eriko Ikeda; Hideaki Kondo; Hisako Ikeyama; Kazutaka Tokushige; Kazufumi Itcho; Yoko Furuichi; Yuya Yoshida; Masaki Matsuda; Kaori Yasuda; Atsushi Doi; Yoshifumi Yokota; Toshiaki Amamoto; Hironori Aramaki; Yasuhiro Irino; Satoru Koyanagi; Shigehiro Ohdo
Journal:  J Biol Chem       Date:  2016-01-04       Impact factor: 5.157

5.  Down-regulation of hepatic cytochrome p450 in chronic renal failure: role of uremic mediators.

Authors:  Carl Guévin; Josée Michaud; Judith Naud; Francois A Leblond; Vincent Pichette
Journal:  Br J Pharmacol       Date:  2002-12       Impact factor: 8.739

6.  The pharmacokinetics of gamma-glutamyl-L-dopa in normal and anephric rats and rats with glycerol-induced acute renal failure.

Authors:  Y A Boateng; H E Barber; T M MacDonald; J C Petrie; M R Lee; P H Whiting
Journal:  Br J Pharmacol       Date:  1990-10       Impact factor: 8.739

7.  Effects of serum from patients with chronic renal failure on rat hepatic cytochrome P450.

Authors:  Josée Michaud; Pierre Dubé; Judith Naud; Francois A Leblond; Karine Desbiens; Alain Bonnardeaux; Vincent Pichette
Journal:  Br J Pharmacol       Date:  2005-04       Impact factor: 8.739

Review 8.  The effect of chronic renal failure on drug metabolism and transport.

Authors:  Albert W Dreisbach; Juan J L Lertora
Journal:  Expert Opin Drug Metab Toxicol       Date:  2008-08       Impact factor: 4.481

9.  Down-regulation of hepatic CYP3A in chronic renal insufficiency.

Authors:  Bhaskar Rege; Richard Krieg; Ning Gao; Mohamadi A Sarkar
Journal:  Pharm Res       Date:  2003-10       Impact factor: 4.200
  9 in total

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